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. 2021 Oct;27(10):1507-1513.
doi: 10.1016/j.cmi.2021.05.033. Epub 2021 Jun 7.

Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients

Maddalena Peghin  1 , Alvisa Palese  2 , Margherita Venturini  2 , Maria De Martino  3 , Valentina Gerussi  4 , Elena Graziano  4 , Giulia Bontempo  4 , Francesco Marrella  4 , Alberto Tommasini  5 , Martina Fabris  6 , Francesco Curcio  6 , Miriam Isola  3 , Carlo Tascini  4
Affiliations

Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients

Maddalena Peghin et al. Clin Microbiol Infect. 2021 Oct.

Abstract

Objectives: To assess the prevalence of and factors associated with post-coronavirus disease 2019 (COVID-19) syndrome 6 months after the onset.

Methods: A bidirectional prospective study. Interviews investigated symptoms potentially associated with COVID-19 6 months after the disease onset of all consecutive adult inpatients and outpatients with COVID-19 attending Udine Hospital (Italy) from March to May 2020. IgG antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were also evaluated 6 months after the onset of symptoms, at the time of the interview.

Results: A total of 599 individuals were included (320 female, 53.4%; mean age 53 years, SD 15.8) and interviewed 187 days (22 SD) after onset. The prevalence of post-COVID-19 syndrome was 40.2% (241/599). The presence of IgG antibodies was significantly associated with the occurrence of post-COVID-19 syndrome (OR 2.56, 95% CI 1.48-4.38, p 0.001) and median SARS-CoV-2 IgG titres were significantly higher in patients with post-COVID-19 syndrome than in patients without symptoms (42.1, IQR 17.1-78.4 vs. 29.1, IQR 12.1-54.2 kAU/L, p 0.004). Female gender (OR 1.55, 95% CI 1.05-2.27), a proportional increase in the number of symptoms at the onset of COVID-19 (OR 1.81, 95% CI 1.59-2.05) and ICU admission OR 3.10, 95% CI 1.18-8.11) were all independent risk factors for post-COVID-19 syndrome. The same predictors also emerged in a subgroup of 231 patients with the serological follow-up available at the time of the interview alongside the proportional increase in anti-SARS-CoV-2 IgG (OR 1.01, 95% CI 1.00-1.02, p 0.04).

Discussion: Prospective follow-up could be offered to specific subgroups of COVID-10 patients, to identify typical symptoms and persistently high anti-SARS-CoV-2 IgG titres as a means of early detection of post-COVID-19 long-term sequelae.

Keywords: COVID survivors; COVID-19; Chronic COVID; Long COVID; Patients with post-COVID-19 syndrome; Post-COVID syndrome; SARS-CoV-2 antibodies; SARS-CoV-2 serology.

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Figures

Fig. 1
Fig. 1
Flow chart of in- and out-patients with COVID-19 attending the Infection Disease Department between March and May 2020. ∧ CORMOR 3-4 protocol.
Fig. 2
Fig. 2
Acute- and post-COVID related sympthoms. Abbreviations: COVID, coronavirus disease; URTI, upper respiratory tract infection.
Fig. 3
Fig. 3
Serological response againts SARS-CoV-2 in patients with or without post-COVID-19 syndrome at 6 months. ∗median (IQR).
See this image and copyright information in PMC

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