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Comment
. 2021 Oct;80(10):e160.
doi: 10.1136/annrheumdis-2021-220736. Epub 2021 Jun 10.

Correspondence on 'Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort'

Jesse Veenstra #  1   2   3 , Jie Wang #  1   2   3 , Kathleen McKinnon-Maksimowicz  4 , Tingting Liu  1   2   3 , Bobby Zuniga  1   2   3 , Iltefat Hamzavi  1 , Li Zhou  1   2   3 , Qing-Sheng Mi  5   2   3
Affiliations
Comment

Correspondence on 'Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort'

Jesse Veenstra et al. Ann Rheum Dis. 2021 Oct.
No abstract available

Keywords: COVID-19; autoimmune diseases; immune system diseases; vaccination.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1.
Figure 1.. IMID patients treated with immunotherapeutics have reduced levels of SARS-CoV-2 vaccine-induced antibody.
A) Semiquantitave anti-RBD IgG levels were measured in 66 healthy controls and 8 IMID patients who had been fully vaccinated for at least 2 weeks. Non-vaccinated healthy participants were included as controls (n=8). The red dashed line (0.7 CI) indicates the cutoff threshold correlating to the presence or absence of antibody per manufacturer (Kantaro and Bio-Techne). Individuals with RBD levels above the 0.7 cutoff threshold moved forward for anti-S IgG quantification. B) Fully quantitative anti-S IgG levels were measured in the study population: Healthy <50 year old (n=55), Healthy ≥ 50 year old (n=11), IMID (n=8), and Control (n=8). Individuals with RBD levels below the 0.7 cutoff level were assigned a value of 0. The red dashed line (25 AU/mL) indicates the threshold correlating to 100% neutralizing antibody levels per manufacturer. Horizontal black bars indicate mean IgG levels. Unpaired two-tailed t test. *P<0.05; ****P<0.0001.
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References

    1. Geisen UM, Berner DK, Tran F, et al.Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort. Ann Rheum Dis 2021. doi: 10.1136/annrheumdis-2021-220272 [published Online First: 2021/03/26] - DOI - PMC - PubMed
    1. Boyarsky BJ, Ruddy JA, Connolly CM, et al.Antibody response to a single dose of SARS-CoV-2 mRNA vaccine in patients with rheumatic and musculoskeletal diseases. Ann Rheum Dis 2021 doi: 10.1136/annrheumdis-2021-220289 [published Online First: 2021/March/25] - DOI - PMC - PubMed
    1. Wajnberg A, Amanat F, Firpo A, et al.Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science 2020;370(6521):1227–30. doi: 10.1126/science.abd7728 [published Online First:2020/October/30] - DOI - PMC - PubMed
    1. Baden LR, El Sahly HM, Essink B, et al.Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. The New England journal of medicine 2021;384(5):403–16. doi: 10.1056/NEJMoa2035389 [published Online First:2020/December/31] - DOI - PMC - PubMed
    1. Polack FP, Thomas SJ, Kitchin N, et al.Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. The New England journal of medicine 2020;383(27):2603–15. doi: 10.1056/NEJMoa2034577 [published Online First:2020/December/11] - DOI - PMC - PubMed