Pharmacokinetics of thallium-201 in normal individuals after routine myocardial scintigraphy

Abstract

Data of pharmacokinetic distribution of and radiation dose from 201Tl chloride used in routine myocardial scintigraphy are based on animal studies or on small groups of humans not exercised. In order to obtain data under routine conditions pharmacokinetics of 201Tl were measured in 15 individuals who had undergone diagnostic myocardial scintigraphy and were classified as normal. Ventral and dorsal whole-body scans were acquired until 9 days after injection. Conjugate pixels were averaged geometrically. Percentage values of total administered dose were obtained for total body and 13 organs by using a calculation method that takes into account the differentiation of overlapping organs.