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Editorial
. 2021 Jul 1;321(1):H208-H213.
doi: 10.1152/ajpheart.00234.2021. Epub 2021 Jun 11.

Reperfused vs. nonreperfused myocardial infarction: when to use which model

Merry L Lindsey  1   2 , Lisandra E de Castro Brás  3 , Kristine Y DeLeon-Pennell  4   5 , Nikolaos G Frangogiannis  6 , Ganesh V Halade  7 , Caitlin C O'Meara  8   9   10 , Francis G Spinale  11 , Zamaneh Kassiri  12 , Jonathan A Kirk  13 , Petra Kleinbongard  14 , Crystal M Ripplinger  15 , Keith R Brunt  16
Affiliations
Editorial

Reperfused vs. nonreperfused myocardial infarction: when to use which model

Merry L Lindsey et al. Am J Physiol Heart Circ Physiol. .

Abstract

There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.

Keywords: cardiac; cardiomyocyte; ischemia-reperfusion; myocardial infarction; rigor and reproducibility.

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Conflict of interest statement

M. L. Lindsey is a Stokes-Shackleford Professor at University of Nebraska Medical Center; Z. Kassiri holds a Canada Research Chair (Tier 1) in Cardiovascular Matrix Remodeling and is a member of the Royal Society of Canada, College of New Scholars; and K. R. Brunt is a Translational Scientist at the New Brunswick Heart Centre. None of the other authors has any conflicts of interest, financial or otherwise, to disclose.

Figures

Figure 1.
Figure 1.
Depending on the questions being addressed (top), ischemia-reperfusion to generate reperfused myocardial infarction (MI) or permanent occlusion to generate nonreperfused MI are the best inputs (middle) to provide particular outputs (bottom).
See this image and copyright information in PMC

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