Cutaneous excitatory and inhibitory input to neurones of the postsynaptic dorsal column system in the cat

Abstract

1. In chloralose-anaesthetized cats single-unit microelectrode recordings were made from axons in the dorsal columns, at the lumbar level, identified as belonging to the postsynaptic dorsal column (PSDC) system. 2. Excitatory and inhibitory receptive field arrangements of a sample of seventy-five PSDC neurones were examined in detail using natural cutaneous stimuli. 3. The sample was characterized by a high degree of convergent input: 80% of units were activated by both light tactile and noxious mechanical stimuli and more than half of those examined were excited by noxious radiant heat. In addition, three-quarters of the units had inhibitory receptive fields on the ipsilateral limb. 4. Twenty-three units (27%) were influenced by input from areas of both hairy and glabrous skin covering the foot and distal limb. Neurones in this group had complex receptive fields, many of which occupied several discontinuous areas of skin. Background and evoked activity of these units could frequently be inhibited by light tactile and/or noxious stimuli. Their inhibitory receptive fields occupied small areas of skin overlapping or adjacent to excitatory fields. 5. Fifty-two units (73%) had receptive fields restricted to areas of hairy skin on the thigh and upper hindlimb. Half the units in this group had coextensive low- and high-threshold excitatory areas but about one-third had a concentric receptive field organization; a high-threshold excitatory component extending beyond, or around, a central low-threshold area. The discharge of these units could be inhibited only by light tactile stimuli. Their inhibitory receptive fields covered extensive areas of skin, sometimes completely surrounding the excitatory field. 6. The complex receptive field arrangements observed for neurones of the postsynaptic dorsal column system are discussed in relation to previous observations on dorsal horn neurones of other ascending tracts.