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. 2021 Jul 5;39(30):4126-4134.
doi: 10.1016/j.vaccine.2021.05.097. Epub 2021 Jun 9.

Respiratory syncytial virus and influenza hospitalizations in Danish children 2010-2016

Andreas Jensen  1 , Eric A F Simões  2 , Claus Bohn Christiansen  3 , Lone Graff Stensballe  4
Affiliations

Respiratory syncytial virus and influenza hospitalizations in Danish children 2010-2016

Andreas Jensen et al. Vaccine. .

Abstract

Objective: To pave the way for universal or risk factor-based vaccination strategies, the present study aimed to describe the epidemiology and compare risk factors for hospitalization associated with respiratory syncytial virus (RSV) and influenza virus infections in Danish children.

Methods: National register-based cohort study among 403,422 Danish children born 2010-2016.

Results: Prior asthma hospitalization, number of children in the household, chronic disease and maternal history of asthma hospitalization were the most important risk factors for both RSV and influenza hospitalization. The incidence of influenza increased at school start.

Conclusions: Our findings enable targeted vaccination programs for high-risk children with asthma-like disease, chronic disease, siblings in the household, or maternal history of asthma hospitalization.

Keywords: Child; Infant; Influenza; Respiratory syncytial virus; Vaccine.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Andreas Jensen, Claus Bohn Christiansen and Lone Graff Stensballe have no conflicts of interest to disclose. Eric A. F. Simões reports grants, personal fees and non-financial support from Astra Zeneca Inc, Merck & Co., Regeneron Inc, Pfizer Inc, and Roche Inc, personal fees, non-financial support and other from Abbvie Inc, personal fees from Alere Inc, and Cidara Inc, other from GSK Inc, grants from Johnson and Johnson, grants and non-financial support from Novavax Inc, outside the submitted work. The study was funded by The Dagmar Marshall Foundation, Denmark.

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