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Clinical Trial
. 1988 Sep 16;260(11):1597-9.

Acyclovir prevents reactivation of herpes simplex labialis in skiers

S L Spruance  1 , M L Hamill, W S Hoge, L G Davis, J Mills
Affiliations
  • PMID: 3411740
Clinical Trial

Acyclovir prevents reactivation of herpes simplex labialis in skiers

S L Spruance et al. JAMA. .

Abstract

To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.

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