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Randomized Controlled Trial
. 2021 Sep;25(9):2801-2814.
doi: 10.1007/s10461-021-03231-x. Epub 2021 Jun 11.

Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention

Marla J Husnik  1   2 , Elizabeth R Brown  1 , Sufia S Dadabhai  3 , Zakir Gaffoor  4 , Nitesha Jeenarain  4 , Flavia Matovu Kiweewa  5 , Edward Livant  6 , Leila E Mansoor  7 , Brenda Gati Mirembe  5 , Thesla Palanee-Phillips  8 , Devika Singh  6 , Samantha Siva  4 , Lydia Soto-Torres  9 , Ariane van der Straten  10   11 , Jared M Baeten  12   13 ; M. T. N.-020/ASPIRE Study Team
Collaborators, Affiliations
Randomized Controlled Trial

Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention

Marla J Husnik et al. AIDS Behav. 2021 Sep.

Abstract

Understanding characteristics associated with adherence to pre-exposure prophylaxis (PrEP) methods for HIV-1 prevention may assist with optimizing implementation efforts. The dapivirine vaginal ring is a novel topical PrEP delivery method. Using data from a randomized, double-blind, placebo-controlled, phase III trial of the dapivirine vaginal ring conducted in four African countries, generalized estimating equation models were used to evaluate correlates of ring adherence. Two levels of quarterly dapivirine blood plasma, and dapivirine released from returned rings defined measures of adherence for recent and cumulative use, respectively. Time on study, calendar time, primary partner knowledge that the participant was taking part in the study, and use of long-acting contraceptive methods were associated with ring adherence whereas younger age, ring worries, condom use, episodes of menstrual bleeding and vaginal washing were associated with non-adherence. These findings may be useful for recruitment into future clinical studies and dapivirine ring implementation efforts.

Keywords: Adherence; Correlates; Dapivirine; HIV-1 prevention; Vaginal ring.

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Conflict of interest statement

Conflict of interest Financial interests—Dr. Jared M. Baeten has received research grants from NIH, CDC, USAID, and Bill & Melinda Gates Foundation. Non-financial interests—Dr. Jared M. Baeten has served on advisory boards for Gilead Sciences, Janssen, and Merck corporations.

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