Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;186(4):543-551.
doi: 10.1007/s11046-021-00569-7. Epub 2021 Jun 12.

Species Distribution and Antifungal Susceptibility Pattern of Candida Recovered from Intensive Care Unit Patients, Vietnam National Hospital of Burn (2017-2019)

Cao Truong Sinh  1 , Cao Ba Loi  2 , Nguyen Thai Ngoc Minh  3 , Nguyen Nhu Lam  4 , Dinh Xuan Quang  5 , Do Quyet  6 , Do Ngoc Anh  7 , Truong Thi Thu Hien  8 , Hoang Xuan Su  9 , Le Tran-Anh  10
Affiliations

Species Distribution and Antifungal Susceptibility Pattern of Candida Recovered from Intensive Care Unit Patients, Vietnam National Hospital of Burn (2017-2019)

Cao Truong Sinh et al. Mycopathologia. 2021 Aug.

Abstract

Introduction: Candida species is the most common cause of invasive fungal infection. With the wide variation in species distribution and antifungal susceptibility of causative agents, local epidemiological profiles are needed to provide effective guidelines for the treatment of invasive candidiasis.

Objective: To find out the species distribution and antifungal susceptibilities of Candida strains isolated from patients in an intensive care unit (ICU) of Vietnam.

Methods: All patients in ICU of Vietnam National Hospital of Burn with Candida isolation reported from January 2017 to December 2019 were retrospectively studied. Species identification and antifungal susceptibility testing were performed using VITEK 2 Compact. The identification was reconfirmed by sequencing of the internal transcribed spacer regions when needed.

Results: A total of 186 yeasts belonging to ten species were collected. The most common agent was C. tropicalis (45.7%), followed by C. albicans (42.4%), and C. parapsilosis (7.53%). The isolated yeasts showed less susceptibility to fluconazole (resistant rate R 10.7%) than to micafungin, caspofungin, flucytosine and amphotericin B (R 0%, 0.6%, 2.3% and 3.4%, respectively, p < 0.05). C. albicans isolates were more susceptible to fluconazole (R 5.2%) than C. tropicalis (R 15.7%). Resistance to voriconazole was seen only among C. albicans (3.9%) and C. tropicalis isolates (9.9%).

Conclusion: Non-albicans species (especially C. tropicalis) is the predominant species, and there is a significant proportion of isolates with reduced susceptibility to azole but not to echinocandin.

Keywords: Antifungal susceptibility; Burn patients; Candida; ICU; Species; Vietnam.

PubMed Disclaimer

References

    1. Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015;373(15):1445–56. - DOI
    1. Enoch DA, Yang H, Aliyu SH, Micallef C. The changing epidemiology of invasive fungal infections. Methods Mol Biol. 2017;1508:17–65. - DOI
    1. Struck MF, Gille J. Fungal infections in burns: a comprehensivereview. Ann Burns Fire Disasters. 2013;XXVI(3):147–53.
    1. Cochran A, Morris S, Edelman L, Saffle J. Systemic Candida infection in burn patients: a case-control study of management patterns and outcomes. Surg Infect. 2002;3(4):367–74. - DOI
    1. Ballard J, Edelman L, Saffle J, et al. Positive fungal cultures in burn patients: a multicenter review. J Burn Care Res. 2008;29(1):213–21. - DOI

LinkOut - more resources