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. 2021 Jun 2:2021:5543822.
doi: 10.1155/2021/5543822. eCollection 2021.

Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study

Huabin Wang  1   2 , Junbin Huang  1   2 , Wenhua Liao  3 , Jiannan Xu  4 , Zhongyuan He  5 , Yong Liu  1   2 , Zhijie He  3 , Chun Chen  1   2
Affiliations

Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study

Huabin Wang et al. Dis Markers. .

Abstract

Objective: The prognostic value of the red cell distribution width (RDW) in patients with sepsis-induced acute respiratory distress syndrome (ARDS) is still elusive. This study is aimed at determining whether RDW is a prognostic indicator of sepsis-induced ARDS.

Methods: This retrospective cohort study included 1161 patients with sepsis-induced ARDS. The datasets were acquired from the Medical Information Mart for Intensive Care III database. The locally weighted scatter-plot smoothing technique, Cox regression, Kaplan-Meier estimator, and subgroup analysis were carried out to evaluate the association between RDW and 90-day mortality.

Results: The RDW and mortality had a roughly linear increasing relationship. The Cox regression model results were as follows: for level 2 (14.5% < RDW < 16.2%), hazard ratio (HR) = 1.35, 95% confidence interval (CI) = 1.03-1.77, and for level 3 (RDW ≥ 16.2%), HR = 2.07, 95% CI = 1.59-2.69. The following results were obtained when RDW was treated as a continuous variable: HR = 1.11, 95%CI = 1.06-1.15. The P values of the interaction between the RDW and covariates were greater than 0.05.

Conclusion: RDW is a new independent prognostic marker for patients with sepsis-induced ARDS.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of patient recruitment.
Figure 2
Figure 2
Relationship between RDW and (a) 90-day or (b) 30-day mortality in sepsis-induced ARDS.
Figure 3
Figure 3
Association between RDW and 90-day overall survival in sepsis-induced ARDS.
Figure 4
Figure 4
Adjusted hazard ratio in the subgroup analysis.
See this image and copyright information in PMC

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