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. 1988 Jun;29(2-3):223-5.
doi: 10.1016/0166-6851(88)90077-1.

Chitinase in female Onchocerca gibsoni and its inhibition by allosamidin

G W Gooday  1 , L J Brydon, L H Chappell
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Chitinase in female Onchocerca gibsoni and its inhibition by allosamidin

G W Gooday et al. Mol Biochem Parasitol. 1988 Jun.

Abstract

Chitinase activity has been detected in female worms of Onchocerca gibsoni. With 3,4-dinitrophenyl-tetra-N-acetylchitotetraoside as substrate 50% of maximum activity was achieved at about 25 microM substrate, with inhibition above 50 microM substrate. The antibiotic allosamidin very strongly inhibited the chitinase activity, 50% inhibition being achieved by 200 pM allosamidin in the presence of 45 microM substrate.

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