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Review
. 2021 May 26:8:684389.
doi: 10.3389/fmed.2021.684389. eCollection 2021.

Synovial Fibrosis Involvement in Osteoarthritis

Li Zhang  1 , Runlin Xing  1   2 , Zhengquan Huang  1   2 , Liang Ding  1   2 , Li Zhang  1   2 , Mingchao Li  1 , Xiaochen Li  1 , Peimin Wang  1   2 , Jun Mao  1   2
Affiliations
Review

Synovial Fibrosis Involvement in Osteoarthritis

Li Zhang et al. Front Med (Lausanne). .

Abstract

Bone changes have always been the focus of research on osteoarthritis, but the number of studies on synovitis has increased only over the last 10 years. Our current understanding is that the mechanism of osteoarthritis involves all the tissues that make up the joints, including nerve sprouting, pannus formation, and extracellular matrix environmental changes in the synovium. These factors together determine synovial fibrosis and may be closely associated with the clinical symptoms of pain, hyperalgesia, and stiffness in osteoarthritis. In this review, we summarize the consensus of clinical work, the potential pathological mechanisms, the possible therapeutic targets, and the available therapeutic strategies for synovial fibrosis in osteoarthritis to gain insight and provide a foundation for further study.

Keywords: extracellular matrix; fibroblast-like synoviocytes; fibrosis; osteoarthritis; synovitis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Potential etiology of synovial fibrosis in OA.
See this image and copyright information in PMC

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