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Review
. 2021 May 26:8:681948.
doi: 10.3389/fcvm.2021.681948. eCollection 2021.

The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Randa M Breikaa  1   2 , Brenda Lilly  1   3
Affiliations
Review

The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Randa M Breikaa et al. Front Cardiovasc Med. .

Abstract

COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.

Keywords: COVID-19; cardiovascular; cardiovascular disease; notch signaling pathway; vascular biology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Notch signaling and COVID-19 shared pathogenic events and resulted cardiovascular complications.
See this image and copyright information in PMC

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