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Review
. 2021 Oct;15(10):353-358.
doi: 10.5489/cuaj.7347.

Results from a Canadian consensus forum of key controversial areas in the management of advanced prostate cancer: Recommendations for Canadian healthcare providers

Affiliations
Review

Results from a Canadian consensus forum of key controversial areas in the management of advanced prostate cancer: Recommendations for Canadian healthcare providers

Fred Saad et al. Can Urol Assoc J. 2021 Oct.

Abstract

Introduction: Rapid progress in diagnostics and therapeutics for the management of prostate cancer (PCa) has created areas where high-level evidence to guide practice is lacking. The Genitourinary Research Consortium (GURC) conducted its second Canadian consensus forum to address areas of controversy in the management of PCa and provide recommendations to guide treatment.

Methods: A panel of PCa specialists discussed topics related to the management of PCa. The core scientific committee finalized the design, questions, and analysis of the consensus results. Attendees then voted to indicate their management choice regarding each statement/topic. Questions for voting were adapted from the 2019 Advanced Prostate Cancer Consensus Conference. The thresholds for agreement were set at ≥75% for "consensus agreement," >50% for "near-consensus," and ≤50% for "no consensus."

Results: The panel was comprised of 29 PCa experts, including urologists (n=12), medical oncologists (n=12), and radiation oncologists (n=5). Voting took place for 65 predetermined questions and three ad hoc questions. Consensus was reached for 34 questions, spanning a variety of areas, including biochemical recurrence, treatment of metastatic castration-sensitive PCa, management of non-metastatic and metastatic castration-resistant PCa, bone health, and molecular profiling.

Conclusions: The consensus forum identified areas of consensus or near-consensus in more than half of the questions discussed. Areas of consensus typically aligned with available evidence, and areas of variability may indicate a lack of high-quality evidence and point to future opportunities for further research and education.

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Conflict of interest statement

Competing interests: Participants received honorarium for participating in the consensus day from the sponsor company. Dr. Saad has received financial support in the forms of honoraria, payments for consulting or advisory role, and or research funding from: AbbVie, Astellas Pharma, AstraZeneca, Bayer, Janssen, Myovant Sciences, Pfizer, Sanofi, Medimmune, and Bristol-Myers Squibb. Dr. Hotte has received financial support in the forms of honoraria, payments for consulting or advisory role, research funding, and or travel, accommodations, expenses from: Astellas Pharma, Bayer, Janssen, Merck, AstraZeneca, Bristol-Myers Squibb, Eisai, Ipsen, Pfizer, Roche, Ayala Pharmaceuticals, Clovis Oncology. Dr. Finelli has received financial support for his consulting or advisory role from AbbVie, Amgen, Astellas Pharma, Bayer, Janssen, TerSera, Sanofi, Knight Pharmaceuticals, and Merck. Dr. Malone has received financial support in the forms of honoraria and travel, accommodations, and expenses from Astellas Pharma, Bayer, Janssen, Sanofi, and TerSera. Dr. Niazi has received financial support in the forms of honoraria, payment for consulting or advisory role, research funding, and travel, accommodations, and expenses from AbbVie, Astellas Pharma, Bayer, Janssen, Sanofi, and TerSera. Dr. Noonan has received financial support in the forms of payment of consulting or advisory role and speaker’s bureau from AstraZeneca, Bristol-Myers Squibb, Ipsen, Janssen, Merck, Pfizer, Roche, and Sanofi. Dr. Shayegan has received financial support in the forms of honoraria, payment for consulting or advisory role, speaker’s bureau, and research funding from AbbVie, Astellas Pharma, Bayer, Janssen, Knight Pharmaceuticals, TerSera, and Merck. Dr. So has received financial support in the forms of payment for consulting or advisory role and participating in clinical trials from Janssen, TerSera, Astellas Pharma, AbbVie, Bayer, Pfizer, and Ferring. Dr. Danielson has received financial support in the form honoraria from Astellas Pharma, Bayer, Janssen, Ferring, and Sanofi. Dr. Basappa has received financial support in the forms of honoraria, payment for consulting or advisory role, and travel, accommodations, and expenses from Astellas Pharma, Eisai, Ipsen, Janssen, Merck, Pfizer, AstraZeneca, Bayer, Bristol-Myers Squibb, and Roche. Dr. Cagiannos has received financial support in the forms of honoraria and travel, accommodations, and expenses from AbbVie, Ferring, and TerSera. Dr. Canil has received financial support in the forms of payments for advisory boards or consultation, educational travel grant, participation in clinical trials, genitourinary research council and medical advisory boards from EMD Serono, Bayer, Janssen, Novartis, AstraZeneca, Bristol-Myers Squibb, Merck, Ipsen, Roche, Ferring, Eisai, Pfizer, Astellas Pharma, Amgen, Sanofi, and Kidney Cancer Canada. Dr. Delouya has received financial support in the forms of payment for participating in speaker’s bureau, advisory board, and grant from Janssen, Sanofi, Bayer, Astellas Pharma, Elekta, Paladin Labs, Ferring, AbbVie, and TerSera. Dr. Fernandes has received financial support in the forms of honoraria, payments for consulting or advisory role, and travel, accommodations, and expenses from Bayer, Merck, Pfizer, Janssen, and Novartis. Dr Ferrario has received financial support in the forms of honoraria, payments for consulting or advisory role, speaker’s bureau, and research funding from AstraZeneca, Bayer, Elli Lilly, Merck, Novartis, Pfizer, Odonate Therapeutics, Roche, Janssen, Astellas Pharma, Immunomedics, Sanofi, and Seattle Genetics. Dr. Gotto has received financial support in the forms of honoraria, payments for consulting or advisory role, expert testimony, and travel, accommodations, expenses from Amgen, Astellas Pharma, Bayer, Janssen, and Merck. Dr. Hamilton has received financial support in the forms of honoraria, research funding, and travel, accommodations, and expenses from AbbVie, Amgen, Astellas Pharma Bayer, and Janssen. Dr. Izard has received financial support in the forms of payments for consulting or advisory role, grants, and participation in clinical trials from Janssen, Astellas Pharma, Bayer, AbbVie, Sanofi, Merck, AstraZeneca, and Pfizer. Dr. Kapoor has received financial support in the forms of payments for consulting or advisory role, honoraria, and research funding from Pfizer, Janssen, Merck, Ipsen, Eisai, Astellas Pharma, and Bristol-Myers Squibb. Dr. Khalaf has received financial support in the forms of payments for consulting or advisory role from Janssen. Dr. Kolinsky has received financial support in the forms of honoraria or consulting from Astellas Pharma, AstraZeneca, Bayer, Bristol-Myers Squibb, Eisai, Ipsen, Janssen, and Merck. Dr. Lalani has received financial support in the forms of payments for consulting or advisory role and grants from AbbVie, Astellas Pharma, AstraZeneca, Bristol-Myers Squibb, Eisai, Ipsen, Janssen, Merck, Novartis, Pfizer, Roche, TerSera, BioCanRx, and EMD Serrono. Dr. Lavallée has received financial support in the forms of payments for consulting or advisory role and educational grant from Ferring, Bayer, Astellas Pharma, Knight Pharmaceuticals, Sanofi, and Janssen. Dr. Morash has received financial support in the forms of payments for consulting or advisory role from Amgen, AbbVie, Bayer, Astellas Pharma, Janssen, TerSera, Knight Pharmaceuticals, Verity Pharmaceuticals, and Sanofi. Dr. Morgan has received financial support in the forms of payments for consulting or advisory role from Astellas Pharma, Bayer, Janssen, and TerSera. Dr. Ong has received financial support in the forms of payments for consulting or advisory role from Janssen and Bayer. Dr. Pouliot has received financial support in the forms of consulting or advisory role from Astellas, Janssen, Bayer, Amgen, TerSear, Sanofi, Merck, Eisai, and Ferring. Dr. Rendon has received financial support in the forms of payments for participation in speaker’s bureau, consulting or advisory role, honoraria or consulting from AbbVie, Amgen, Astellas Pharma, AstraZeneca, Bayer, Ferring, Janssen and Sanofi. Dr. Yip has received financial support in the forms of payments for consulting or advisory role, grans, and investments from Astellas Pharma, AstraZeneca, Bayer, Bristol-Myers Squibb, Novartis, Pfizer, Roche, Janssen, and Merck. Anousheh Zardan and Laura Park-Wyllie are full time employees of Janssen. Dr. Chi has received financial support in the forms of honoraria and/or consulting fees from Astellas Pharma, AstraZeneca Daiichi Sankyo, Janssen, Novartis, Pfizer, Point Biopharma, Roche, and Sanofi.

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