Knowledge bases and software support for variant interpretation in precision oncology

Florian Borchert¹, Andreas Mock^{2

3}, Aurelie Tomczak^{4

5}, Jonas Hügel^{6

7}, Samer Alkarkoukly⁸, Alexander Knurr⁹, Anna-Lena Volckmar⁴, Albrecht Stenzinger⁴, Peter Schirmacher^{4

5}, Jürgen Debus^{10

11

12

13

14}, Dirk Jäger^{3

15}, Thomas Longerich^{4

5}, Stefan Fröhling^{2

16}, Roland Eils^{17

18}, Nina Bougatf^{10

11

12

13

14}, Ulrich Sax^{6

7}, Matthieu-P Schapranow¹

Affiliations

¹ Digital Health Center, Hasso Plattner Institute (HPI), University of Potsdam, Prof.-Dr.-Helmert-Str. 2-3, 14482 Potsdam, Germany.
² Department of Translational Medical Oncology (TMO), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
³ Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁴ Institute of Pathology Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
⁵ Liver Cancer Center Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁶ Department of Medical Informatics, University Medical Center Göttingen, Von-Siebold-Str. 3, 37099 Göttingen, Germany.
⁷ Campus Institute Data Science, Göttingen, Germany.
⁸ CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne.
⁹ Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁰ Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹¹ National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
¹² Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹³ Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 450, 69120 Heidelberg, Germany.
¹⁴ Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹⁵ Clinical Coorporation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁶ German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
¹⁷ Health Data Science Unit, Heidelberg University Hospital, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
¹⁸ Center for Digital Health, Berlin Institute of Health and Charité Universitötsmedizin Berlin, Kapelle-Ufer 2, 10117 Berlin, Germany.

PMID: 34125166
PMCID: PMC8575010
DOI: 10.1093/bib/bbab246

Published Erratum

Knowledge bases and software support for variant interpretation in precision oncology

Florian Borchert et al. Brief Bioinform. 2021.

. 2021 Nov 5;22(6):bbab246.

doi: 10.1093/bib/bbab246.

Authors

Affiliations

¹ Digital Health Center, Hasso Plattner Institute (HPI), University of Potsdam, Prof.-Dr.-Helmert-Str. 2-3, 14482 Potsdam, Germany.
² Department of Translational Medical Oncology (TMO), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
³ Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁴ Institute of Pathology Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
⁵ Liver Cancer Center Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
⁶ Department of Medical Informatics, University Medical Center Göttingen, Von-Siebold-Str. 3, 37099 Göttingen, Germany.
⁷ Campus Institute Data Science, Göttingen, Germany.
⁸ CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne.
⁹ Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁰ Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹¹ National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
¹² Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹³ Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 450, 69120 Heidelberg, Germany.
¹⁴ Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
¹⁵ Clinical Coorporation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
¹⁶ German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
¹⁷ Health Data Science Unit, Heidelberg University Hospital, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
¹⁸ Center for Digital Health, Berlin Institute of Health and Charité Universitötsmedizin Berlin, Kapelle-Ufer 2, 10117 Berlin, Germany.

PMID: 34125166
PMCID: PMC8575010
DOI: 10.1093/bib/bbab246

No abstract available

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Erratum for

Knowledge bases and software support for variant interpretation in precision oncology.
Borchert F, Mock A, Tomczak A, Hügel J, Alkarkoukly S, Knurr A, Volckmar AL, Stenzinger A, Schirmacher P, Debus J, Jäger D, Longerich T, Fröhling S, Eils R, Bougatf N, Sax U, Schapranow MP. Borchert F, et al. Brief Bioinform. 2021 Nov 5;22(6):bbab134. doi: 10.1093/bib/bbab134. Brief Bioinform. 2021. PMID: 33971666 Free PMC article.

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Knowledge bases and software support for variant interpretation in precision oncology

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Knowledge bases and software support for variant interpretation in precision oncology

Authors

Affiliations

Erratum for

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