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. 2022 Jan;86(1):46-54.
doi: 10.1016/j.jaad.2021.06.023. Epub 2021 Jun 11.

Adverse pregnancy and maternal outcomes in women with hidradenitis suppurativa

Laura Fitzpatrick  1 , Jennifer Hsiao  2 , Rachel Tannenbaum  1 , Andrew Strunk  1 , Amit Garg  3
Affiliations

Adverse pregnancy and maternal outcomes in women with hidradenitis suppurativa

Laura Fitzpatrick et al. J Am Acad Dermatol. 2022 Jan.

Abstract

Background: Hidradenitis suppurativa (HS) disproportionately affects women of childbearing age. However, pregnancy and maternal outcomes for women with HS are unknown.

Objective: To compare risk of adverse pregnancy and maternal outcomes among women with and without HS and to evaluate the influence of comorbid conditions.

Methods: Retrospective cohort analysis between January 1, 2011, and September 30, 2015.

Results: Compared to control pregnancies (n = 64,218), HS pregnancies (n = 1862) had a higher risk of spontaneous abortion (15.5% vs 11.3%), preterm birth (9.1% vs 6.7%), gestational diabetes mellitus (11.6% vs 8.4%), gestational hypertension (6.1% vs 4.4%), preeclampsia (6.6% vs 3.8%), and cesarean section (32.4% vs 27.1%). Relative risk of some pregnancy and maternal outcomes were attenuated after comorbidity adjustment. In the fully adjusted model, HS pregnancies were independently associated with spontaneous abortion (odds ratio, 1.20; 95% CI, 1.04-1.38), gestational diabetes mellitus (odds ratio, 1.26; 95% CI, 1.07-1.48), and cesarean section (odds ratio, 1.09; 95% CI, 1.004-1.17).

Limitations: We could not evaluate potential influences of disease duration, activity, or severity. Newborn outcomes could not be evaluated.

Conclusion: HS appears to be an independent risk factor for adverse pregnancy and maternal outcomes. This risk is influenced by comorbidities that may be modifiable with early identification and management.

Keywords: Explorys; epidemiology; hidradenitis suppurativa; maternal; outcomes; pregnancy; women.

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Conflict of interest statement

Conflicts of interest Dr Hsiao has served as an advisor for Novartis. Dr Garg is an advisor for AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, InflaRx, Incyte, Janssen, Novartis, Pfizer, UCB, and Viela Biosciences, and receives research grants from AbbVie and National Psoriasis Foundation. Dr Fitzpatrick and Authors Tannenbaum and Strunk have no conflicts of interest to declare.