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Review
. 2021 Sep 1;37(5):498-503.
doi: 10.1097/MOG.0000000000000762.

Complications of chronic pancreatitis in children

Emily Perito  1 , Tanja Gonska  2 , Melena D Bellin  3 , Sarah Jane Schwarzenberg  4
Affiliations
Review

Complications of chronic pancreatitis in children

Emily Perito et al. Curr Opin Gastroenterol. .

Abstract

Purpose of review: In children, chronic pancreatitis is infrequent but may be associated with serious complications, including severe pain that limits activities, exocrine and endocrine pancreatic insufficiency and malnutrition. Investigation into pediatric chronic pancreatitis has transitioned from single center reports to multicenter, protocol-driven studies. As a result, we now have information on much larger numbers of children with chronic pancreatitis, allowing a more reliable understanding of the complications of chronic pancreatitis.

Recent findings: A high percentage of children with chronic pancreatitis use opioids frequently to control pain. About a quarter of children with chronic pancreatitis have exocrine pancreatic insufficiency, and about 6% have pancreatogenic diabetes. Mild malnutrition and low bone density are both common in children with chronic pancreatitis.

Summary: Large multicenter and single-center observational studies have allowed us to more accurately assess complications of chronic pancreatitis in children. These studies demonstrate the need for examination of therapies for these complications in children.

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Conflict of interest statement

Conflicts of Interest

MB receives research support from Viacyte, Dexcom and consults (DSMB membership) for Insulet; SJS receives grant and consultation funding from the Cystic Fibrosis Foundation and royalties from UpToDate, EP and TG hve no conflicts of interest.

References

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