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Clinical Trial
. 2021 Jun 14;11(1):12488.
doi: 10.1038/s41598-021-92065-7.

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Tongtian Ni  1 , Ying Chen  1 , Bing Zhao  1 , Li Ma  1 , Yi Yao  1 , Erzhen Chen  1 , Weijun Zhou  2 , Enqiang Mao  3
Affiliations
Clinical Trial

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Tongtian Ni et al. Sci Rep. .

Abstract

Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups were analyzed. Of the 181 patients included in the analysis, the FRVC group received more fluid volume and reached the endpoint of blood volume expansion ahead of the non-FRVC group. After the early fluid resuscitation, the inflammation indicators in the FRVC group were lower. The rate of mechanical ventilation and the incidence of hypernatremia also decreased significantly. Using pure water for FRVC was more helpful to reduce hypernatremia. However, Kaplan-Meier 90-day survival between the two groups showed no difference. These results suggest that the combination of FRVC might benefit SAP patients in the early stage of fluid resuscitation, but there is no difference between the prognosis of SAP patients and that of conventional fluid resuscitation. Further prospective study is needed to evaluate the effect of FRVC on SAP patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart describing the patients with severe acute pancreatitis between Jan 2014 ~ Dec 2018. SAP: severe acute pancreatitis, FRVC: fluid resuscitation via colon.
Figure 2
Figure 2
Kaplan–Meier 90-day survival between FRVC and non-FRVC groups in patients with severe acute pancreatitis. FRVC: fluid resuscitation via colon.
See this image and copyright information in PMC

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