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Review
. 2021 Jan;63(1):e12240.
doi: 10.1002/1348-9585.12240.

Lung disorders induced by respirable organic chemicals

Yasuo Morimoto  1 , Chinatsu Nishida  2 , Taisuke Tomonaga  1 , Hiroto Izumi  1 , Kazuhiro Yatera  2 , Kazuo Sakurai  3 , Yangho Kim  4
Affiliations
Review

Lung disorders induced by respirable organic chemicals

Yasuo Morimoto et al. J Occup Health. 2021 Jan.

Erratum in

Abstract

Respirable organic chemicals were originally thought to cause allergic respiratory diseases, such as bronchial asthma and hypersensitivity pneumonitis, and believed not to cause lung disorders derived from inflammatory or fibrotic processes such as pulmonary fibrosis and interstitial pneumonitis. It has recently been reported, however, that exposure to organic chemicals can cause interstitial lung diseases. In this review, we discuss the clinical features of occupational asthma and hypersensitivity pneumonitis, as well as other lung disorders, including interstitial pneumonitis, caused by humidifier disinfectants in Korea and by a cross-linked acrylic acid-based polymer (CL-PAA) in Japan.

Keywords: lung; occupational asthma; organic chemicals; polymer.

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Conflict of interest statement

Ethical approval: N/A. Informed consent: N/A. Registry and the registration no. of the study/trial: N/A. Animal studies: All procedures and animal handling were done according to the guidelines described in the Japanese Guide for the Care and Use of Laboratory Animals as approved by the Animal Care and Use Committee, University of Occupational and Environmental Health, Japan. Conflict of interest: We declare no conflict of interest associated with this manuscript.

Figures

FIGURE 1
FIGURE 1
Structural formula of organic chemicals
FIGURE 2
FIGURE 2
A‐F, Comparison of pathological findings between polyacrylic acid (molecular weight 450 000), asbestos (chrysotile), and crystalline silica‐exposed lungs at 3 days following instillation. Pulmonary inflammation from exposure to polyacrylic acid was more pronounced than that in crystalline silica and asbestos administered at the same dosage
See this image and copyright information in PMC

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