Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 7;50(15):8355-8360.
doi: 10.1039/d1cs00044f. Epub 2021 Jun 15.

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Barry Halliwell  1 , Amitava Adhikary, Michael Dingfelder, Miral Dizdaroglu
Affiliations
Review

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Barry Halliwell et al. Chem Soc Rev. .

Abstract

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO3˙-) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Products resulting from attack of hydroxyl radicals on DNA
By contrast, carbonate anion radical modifies only guanine residues
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Halliwell B and Gutteridge JMC, Free Radicals in Biology and Medicine. 2015, Clarendon Press, Oxford; (fifth edition), UK.
    1. Pryor WA, Free Radic. Biol. Med, 1988, 4, 219. - PubMed
    1. Halliwell B, Free Radic. Biol. Med, 2020, 161, 234. - PMC - PubMed
    1. Hayes JD, Dinkova-Kostova AT and Tew KD, Cancer Cell, 2020, 38, 167. - PMC - PubMed
    1. Halliwell B, Biochem. J, 2007, 401, 1. - PubMed