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Review
. 2021 Aug 7;50(15):8355-8360.
doi: 10.1039/d1cs00044f. Epub 2021 Jun 15.

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Barry Halliwell  1 , Amitava Adhikary, Michael Dingfelder, Miral Dizdaroglu
Affiliations
Review

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Barry Halliwell et al. Chem Soc Rev. .

Abstract

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO3˙-) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.

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Figures

Figure 1.
Figure 1.. Products resulting from attack of hydroxyl radicals on DNA
By contrast, carbonate anion radical modifies only guanine residues
See this image and copyright information in PMC

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