Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jun;76(6):1943-1944.
doi: 10.1111/all.14761.

COVID-19 vaccines and the role of other potential allergenic components different from PEG. A reply to: "Other excipients than PEG might cause serious hypersensitivity reactions in COVID-19 vaccines"

Beatriz Cabanillas  1 , Cezmi A Akdis  2   3 , Natalija Novak  4
Affiliations
Comment

COVID-19 vaccines and the role of other potential allergenic components different from PEG. A reply to: "Other excipients than PEG might cause serious hypersensitivity reactions in COVID-19 vaccines"

Beatriz Cabanillas et al. Allergy. 2021 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

CA reports grants from Allergopharma, Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission Horizon 2020 Framework Programme, Cure, Novartis Research Institutes, AstraZeneca, SciBase, advisory role for Sanofi/Regeneron, GlaxoSmithKline, SciBase, and Novartis, outside the submitted work. NN and BC declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Active components and excipients listed in BNT162b2, mRNA‐1273, and AZD1222 vaccines. The principles of the PEGylated‐lipid nanoparticles as a delivery system for the mRNA in BNT162b2, mRNA‐1273 vaccines are depicted in the upper part together to the replication‐deficient adenovirus ChAdOx1 vector containing the gene of the glycoprotein spike (S) antigen of SARS‐CoV‐2 for the AZD1222 vaccine. Potential triggers of allergic reactions are indicated in red color in the excipient lists of each vaccine
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Borgsteede S, Geersing TH, Tempels‐Pavlica Z. Other excipients than PEG might cause serious hypersensitivity reactions in COVID‐19 vaccines. Allergy 2021;76(6):1941‐1942. - PMC - PubMed
    1. Cabanillas B, Akdis C, Novak N. Allergic reactions to the first COVID‐19 vaccine: a potential role for polyethylene glycol?. Allergy 2021;76(6):1617‐1618. - PubMed
    1. Klimek L, Novak N, Cabanillas B, et al. Allergenic components of the mRNA‐1273 vaccine for COVID‐19: possible involvement of polyethylene glycol and IgG‐mediated complement activation. Allergy 2021. 10.1111/all.14794 - DOI - PMC - PubMed
    1. Lukawska J, Mandaliya D, Chan AWE, et al. Anaphylaxis to trometamol excipient in gadolinium‐based contrast agents for clinical imaging. J Allergy Clin Immunol Pract. 2019;7(3):1086‐1087. - PubMed
    1. Castells MC, Phillips EJ. Maintaining safety with SARS‐CoV‐2 vaccines. N Engl J Med. 2020; 10.1056/NEJMra2035343 - DOI - PMC - PubMed