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Review
. 2021 Dec;112(12):e23460.
doi: 10.1002/bip.23460. Epub 2021 Jun 15.

Peptide nucleic acids and their role in gene regulation and editing

J Dinithi R Perera  1 , Kelly E W Carufe  1 , Peter M Glazer  1   2
Affiliations
Review

Peptide nucleic acids and their role in gene regulation and editing

J Dinithi R Perera et al. Biopolymers. 2021 Dec.

Abstract

The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be used in therapeutic and biotechnological interventions. It has been broadly utilized for numerous applications, with a major focus in regulation of gene expression, and more recently in gene editing. While the classic PNA design has mainly been employed to date, chemical modifications of the PNA backbone and nucleobases provide an avenue to advance the technology further. This review aims to discuss the recent developments in PNA based gene manipulation techniques and the use of novel chemical modifications to improve the current state of PNA mediated gene targeting.

Keywords: PNA delivery; PNA modifications; gene editing; gene regulation; peptide nucleic acids.

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References

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