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Review
. 2021 May 24;12(5):309-322.
doi: 10.5306/wjco.v12.i5.309.

COVID-19: Where is the treatment?

Bonala Sabeerabi  1 , Sarojamma Vemula  2 , Ramakrishna Vadde  3 , Ganji Purnachandra Nagaraju  4
Affiliations
Review

COVID-19: Where is the treatment?

Bonala Sabeerabi et al. World J Clin Oncol. .

Abstract

Even though the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is related to SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), identifying effective and safe therapeutic strategies remains challenging. In search of finding effective treatments to eradicate the virus and improve disease symptoms, scientists are exploring possible therapies such as anti-viral, anti-malaria, immune therapy, and hormone treatments. However, the efficacy of these treatments was not validated on either SARS-CoV or MERS-CoV. In this study, we have reviewed synthetic evidence achieved through systematic and meta-analysis of therapeutics specific for SARS-CoV-2 and observed that the use of the above-mentioned therapies had no clinical benefits in coronavirus disease 2019 patients and, conversely, displayed side effects.

Keywords: Anti-viral drugs; COVID-19; Corticosteroids; Immune therapy; Meta-analysis; Therapeutics.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no potential conflict of interest for this article.

Figures

Figure 1
Figure 1
Coronavirus disease 2019 and its possible treatments. COVID-19: Coronavirus disease 2019; ACEI: Angiotensin-converting enzyme inhibitors; ARB: Angiotensin receptor blockers; IgG: Immunoglobulin G.
See this image and copyright information in PMC

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