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Review
. 2021 Sep;98(3):377-394.
doi: 10.1111/cbdd.13858. Epub 2021 Jun 15.

Temporal Lobe Epilepsy: What do we understand about protein alterations?

Nadia Perveen  1 , Waseem Ashraf  1 , Faleh Alqahtani  2 , Muhammad Fawad Rasool  3 , Noreen Samad  4 , Imran Imran  1
Affiliations
Review

Temporal Lobe Epilepsy: What do we understand about protein alterations?

Nadia Perveen et al. Chem Biol Drug Des. 2021 Sep.

Abstract

During neuronal diseases, neuronal proteins get disturbed due to changes in the connections of neurons. As a result, neuronal proteins get disturbed and cause epilepsy. At the genetic level, many mutations may take place in proteins like axon guidance proteins, leucine-rich glioma inactivated 1 protein, microtubular protein, pore-forming, chromatin remodeling, and chemokine proteins which may lead toward temporal lobe epilepsy. These proteins can be targeted in the future for the treatment purpose of epilepsy. Novel avenues can be developed for therapeutic interventions by these new insights.

Keywords: axon guidance protein; chemokine; chromatin remodeling proteins; inactivated (LGI) protein; leucine; microtubule-associated proteins; rich glioma.

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