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Review
. 2021 Jun 14;54(9):e11055.
doi: 10.1590/1414-431X2021e11055. eCollection 2021.

Biomaterials for bone regeneration: an orthopedic and dentistry overview

J Girón  1   2 , E Kerstner  3 , T Medeiros  1   2 , L Oliveira  1 , G M Machado  4 , C F Malfatti  3 , P Pranke  1   2   5
Affiliations
Review

Biomaterials for bone regeneration: an orthopedic and dentistry overview

J Girón et al. Braz J Med Biol Res. .

Abstract

Because bone-associated diseases are increasing, a variety of tissue engineering approaches with bone regeneration purposes have been proposed over the last years. Bone tissue provides a number of important physiological and structural functions in the human body, being essential for hematopoietic maintenance and for providing support and protection of vital organs. Therefore, efforts to develop the ideal scaffold which is able to guide the bone regeneration processes is a relevant target for tissue engineering researchers. Several techniques have been used for scaffolding approaches, such as diverse types of biomaterials. On the other hand, metallic biomaterials are widely used as support devices in dentistry and orthopedics, constituting an important complement for the scaffolds. Hence, the aim of this review is to provide an overview of the degradable biomaterials and metal biomaterials proposed for bone regeneration in the orthopedic and dentistry fields in the last years.

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Figures

Figure 1
Figure 1. The number of annual publications in the PubMed database from 2005 to May 2020 using the terms: (Bone Regeneration[MeSH Terms]), (Tissue Scaffolds[MeSH Terms]) and (Metals). November 16, 2020. BR: bone regeneration.
Figure 2
Figure 2. Distribution of manufacturing techniques cited for scaffolds with a bone regeneration objective. Each term has been associated with AND “Bone Regeneration”[MeSH]. June 1, 2020.
Figure 3
Figure 3. Graph showing polymer distribution in publications retrieved from a search in the PubMed database with the terms: “Chitin”[MeSH], “Collagen”[MeSH], “Gelatin”[MeSH], “Alginates”[MeSH], “Hyaluronic Acid”[MeSH], “Polycaprolactone” [Supplementary Concept], “Polyvinyls”[MeSH], “Polylactic Acid-Polyglycolic Acid Copolymer”[MeSH]. Each term has been associated with AND “Bone Regeneration” [MeSH]. June 1, 2020.
Figure 4
Figure 4. Graph showing ceramic distribution in publications retrieved from a search in the PubMed database using the following terms: “Hydroxyapatites”[MeSH], “Calcium Phosphate”[MeSH], “Glass”]MeSH]. Each term has been associated with AND “Bone Regeneration” [MeSH]. June 1, 2020.
Figure 5
Figure 5. Graph showing metals distribution in publications retrieved from a search in the PubMed database using the following terms: “Titanium”, “Silver”, “Magnesium”, “Niobium”, “Strontium”, “Stainless Steel” and “Cobalt”. Each term has been associated with “AND “Bone Regeneration” [MeSH]. June 1, 2020.
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