In response to the letter to the editor by Soha Ghanian et al. re our publication "Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males"

Andrea M Isidori¹, Marco Marcelli², Maria Grazia Castagna³, Margherita Baldassarri⁴, Francesca Fava⁵, Alessandra Renieri⁶

Affiliations

¹ Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
² Department of Medicine, Baylor College of Medicine, Houston TX, USA.
³ Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy.
⁴ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy.
⁵ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy.
⁶ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy. Electronic address: alessandra.renieri@unisi.it.

PMID: 34134089
PMCID: PMC8197779
DOI: 10.1016/j.ebiom.2021.103426

Comment

In response to the letter to the editor by Soha Ghanian et al. re our publication "Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males"

Andrea M Isidori et al. EBioMedicine. 2021 Jun.

. 2021 Jun:68:103426.

doi: 10.1016/j.ebiom.2021.103426. Epub 2021 Jun 13.

Authors

Andrea M Isidori¹, Marco Marcelli², Maria Grazia Castagna³, Margherita Baldassarri⁴, Francesca Fava⁵, Alessandra Renieri⁶

Affiliations

¹ Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
² Department of Medicine, Baylor College of Medicine, Houston TX, USA.
³ Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy.
⁴ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy.
⁵ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy.
⁶ Medical Genetics, University of Siena, Italy; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy. Electronic address: alessandra.renieri@unisi.it.

PMID: 34134089
PMCID: PMC8197779
DOI: 10.1016/j.ebiom.2021.103426

No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors have no competing interests.

Comment on

Letter to the Editor re: Baldassarri et al., 2021 "Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males".
Ghanian S, Wambier CG. Ghanian S, et al. EBioMedicine. 2021 Jun;68:103425. doi: 10.1016/j.ebiom.2021.103425. Epub 2021 Jun 13. EBioMedicine. 2021. PMID: 34134086 Free PMC article. No abstract available.

References

1. Cadegiani FA, McCoy J, Gustavo Wambier C, Goren A. Early antiandrogen therapy with dutasteride reduces viral shedding, inflammatory responses, and time-to-remission in males with COVID-19: a randomized, double-blind, placebo-controlled interventional trial (EAT-DUTA AndroCoV Trial - Biochemical) Cureus. 2021;13:e13047. - PMC - PubMed
1. Farina N, Ramirez GA, De Lorenzo R, Di Filippo L, Conte C, Ciceri F, Manfredi AA, Rovere-Querini P. COVID-19: pharmacology and kinetics of viral clearance. Pharmacol Res. 2020 Nov;161 doi: 10.1016/j.phrs.2020.105114. - DOI - PMC - PubMed
1. Baldassarri M. Shorter androgen receptor polyQ alleles protect against life- threatening COVID-19 disease in European males. EBioMedicine. 2021 - PMC - PubMed
1. Klein EA, Li J, Milinovich A, Schold JD, Sharifi N, Kattan MW, Jehi L. Androgen deprivation therapy in men with prostate cancer does not affect risk of infection with SARS-CoV-2. J Urol. 2021 Feb;205(2):441–443. doi: 10.1097/JU.0000000000001338. Epub 2020 Sep 8. PMID: 32897764. - DOI - PubMed
1. McCoy J. Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients. J Eur Acad Dermatol. Venereol. 2020;35(1):e15–e17. - PMC - PubMed

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In response to the letter to the editor by Soha Ghanian et al. re our publication "Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males"

Affiliations

In response to the letter to the editor by Soha Ghanian et al. re our publication "Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males"

Authors

Affiliations

Conflict of interest statement

Comment on

References

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Medical