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. 1988 Sep 2;241(4870):1188-91.
doi: 10.1126/science.3413482.

Induction of an antibody that catalyzes the hydrolysis of an amide bond

K D Janda  1 , D Schloeder, S J Benkovic, R A Lerner
Affiliations

Induction of an antibody that catalyzes the hydrolysis of an amide bond

K D Janda et al. Science. .

Abstract

Catalysis of amide bond hydrolysis is of singular importance in enzymology. An antibody was induced to an analog of a high-energy intermediate anticipated along the reaction coordinate of amide hydrolysis. This antibody is an amidase with high specificity and a large rate enhancement (250,000) relative to the uncatalyzed reaction. This reaction represents the kinetically most difficult hydrolysis reaction yet catalyzed by an antibody.

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