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. 2021 Jun 9;11(4):e12014.
doi: 10.1002/clt2.12014. eCollection 2021 Jun.

ARIA-EAACI care pathways for allergen immunotherapy in respiratory allergy

Jean Bousquet  1   2   3 , Oliver Pfaar  4 , Ioana Agache  5 , Anna Bedbrook  3 , Cezmi A Akdis  6 , G Walter Canonica  7   8 , Tomas Chivato  9 , Mona Al-Ahmad  10   11 , Amir H Abdul Latiff  12 , Ignacio J Ansotegui  13 , Claus Bachert  14   15   16 , Abdullah Baharuddin  17 , Karl-Christian Bergmann  1 , Carsten Bindslev-Jensen  18   16   19 , Leif Bjermer  20 , Matteo Bonini  21   22 , Sinthia Bosnic-Anticevich  23   24 , Isabelle Bosse  25 , Helen A Brough  26 , Luisa Brussino  27 , Moises A Calderon  28 , Luis Caraballo  29   30 , Victoria Cardona  31 , Pedro Carreiro-Martins  32   33 , Tomas Casale  34 , Lorenzo Cecchi  35 , Alfonso M Cepeda Sarabia  36   37 , Ekaterine Chkhartishvili  38 , Derek K Chu  39 , Ieva Cirule  40 , Alvaro A Cruz  41 , Wienczyslawa Czarlewski  42 , Stefano Del Giacco  43 , Pascal Demoly  44   45 , Philippe Devillier  46 , Dejan Dokic  47 , Stephen L Durham  48 , Motohiro Ebisawa  49 , Yehia El-Gamal  50 , Regina Emuzyte  51 , Amiran Gamkrelidze  52 , Jean Luc Fauquert  53 , Alessandro Fiocchi  54 , Wytske J Fokkens  55   56 , Joao A Fonseca  57   58 , Jean-François Fontaine  59 , Radoslaw Gawlik  60 , Asli Gelincik  61 , Bilun Gemicioglu  62 , Jose E Gereda  63 , Roy Gerth van Wijk  64 , R Maximiliano Gomez  65 , Maia Gotua  66 , Ineta Grisle  67 , Maria-Antonieta Guzmán  68 , Tari Haahtela  69 , Susanne Halken  70 , Enrico Heffler  7 , Karin Hoffmann-Sommergruber  71 , Elham Hossny  50 , Martin Hrubiško  72 , Carla Irani  73 , Juan Carlos Ivancevich  74 , Zhanat Ispayeva  75 , Kaja Julge  76 , Igor Kaidashev  77 , Omer Kalayci  78 , Musa Khaitov  79 , Ludger Klimek  80   81 , Edward Knol  82 , Marek L Kowalski  83 , Helga Kraxner  84 , Inger Kull  85   86 , Piotr Kuna  87 , Violeta Kvedariene  88   89 , Vicky Kritikos  90   91 , Antti Lauerma  92 , Susanne Lau  93 , Daniel Laune  94 , Michael Levin  95 , Desiree E Larenas-Linnemann  96 , Karin C Lodrup Carlsen  97   98 , Carlo Lombardi  99 , Olga M Lourenço  100 , Bassam Mahboub  101 , Hans-Jørgen Malling  102 , Patrick Manning  103 , Gailen D Marshall  104 , Erik Melén  105   86 , Eli O Meltzer  106 , Neven Miculinic  107 , Branislava Milenkovic  108   109 , Mostafa Moin  110 , Stephen Montefort  111 , Mario Morais-Almeida  112 , Charlotte G Mortz  18 , Ralph Mösges  113 , Joaquim Mullol  114   115 , Leyla Namazova Baranova  116 , Hugo Neffen  117 , Kristof Nekam  118 , Marek Niedoszytko  119 , Mikaëla Odemyr  120 , Robyn E O'Hehir  121   122 , Markus Ollert  123   124 , Liam O'Mahony  125 , Ken Ohta  126 , Yoshitaka Okamoto  127 , Kimi Okubo  128 , Giovanni B Pajno  129 , Oscar Palomares  130 , Susanna Palkonen  131 , Petr Panzner  131 , Nikolaos G Papadopoulos  132 , Hae-Sim Park  133 , Giovanni Passalacqua  134 , Vincenzo Patella  135 , Ruby Pawankar  136 , Nhân Pham-Thi  137 , Davor Plavec  138 , Todor A Popov  139 , Marysia Recto  140 , Frederico S Regateiro  141   142   143 , Carmen Riggioni  144   145 , Graham Roberts  146 , Monica Rodriguez-Gonzales  147 , Nelson Rosario  148 , Menachem Rottem  149   150 , Philip W Rouadi  151 , Dermot Ryan  152 , Boleslaw Samolinski  153 , Mario Sanchez-Borges  154 , Faradiba S Serpa  155 , Joaquin Sastre  156 , Glenis K Scadding  157 , Mohamed H Shamji  158   159 , Peter Schmid-Grendelmeier  160 , Holger J Schünemann  39 , Aziz Sheikh  161 , Nicola Scichilone  162 , Juan Carlos Sisul  163 , Mikhail Sofiev  164 , Dirceu Solé  165 , Talant Sooronbaev  166 , Manuel Soto-Martinez  167 , Manuel Soto-Quiros  168 , Milan Sova  169 , Jürgen Schwarze  170 , Isabel Skypala  171 , Charlotte Suppli-Ulrik  172   173 , Luis Taborda-Barata  174   175 , Ana Todo-Bom  176   177 , Maria J Torres  178 , Marylin Valentin-Rostan  179 , Peter-Valentin Tomazic  180 , Antonio Valero  181 , Sanna Toppila-Salmi  69 , Ioanna Tsiligianni  182   183 , Eva Untersmayr  184 , Marilyn Urrutia-Pereira  185 , Arunas Valiulis  186   187 , Erkka Valovirta  188   189 , Olivier Vandenplas  190 , Maria Teresa Ventura  191 , Pakit Vichyanond  192 , Martin Wagenmann  193 , Dana Wallace  194 , Jolanta Walusiak-Skorupa  195 , De Yun Wang  196 , Susan Waserman  197 , Gary Wk Wong  198 , Arzu Yorgancioglu  199 , Osman M Yusuf  200 , Mario Zernotti  201 , Luo Zhang  202   203 , Mihaela Zidarn  204 , Torsten Zuberbier  1 , Marek Jutel  205   206
Affiliations

ARIA-EAACI care pathways for allergen immunotherapy in respiratory allergy

Jean Bousquet et al. Clin Transl Allergy. .
No abstract available

Keywords: allergic rhinitis; asthma; immunotherapy; precision medicine.

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Conflict of interest statement

IAgache is an Associate Editor Allergy and CTA. CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission's Horison's 2020 Framework Programme, Cure, Novartis Research Institutes, Astra Zeneca, scibase, advisory role in Sanofi/Regeneron, grants from Glakso Smith‐Kline, advisory role in scibase. IA reports personal fees from Hikma, Roxall, Astra Zeneca, Menarini, UCB, Faes Farma, Sanofi, Mundipharma, Bial, Amgen, Stallergenes. SBA reports grants from TEVA, personal fees from TEVA, AstraZeneca, Boehringer Ingelheim, GSK, Sanofi, Mylan. VC reports personal fees from ALK, Allergy Therapeutics, LETI, Thermofisher, Merck, Astrazeneca, GSK. TC reports grants and personal fees from Stallergenes. PD reports personal fees from ALK‐Abello, Stallergenes‐Greer, Astra Zeneca, GlaxoSmithKline, Mylan, Sanofi. SD reports personal fees and non‐financial support from ALK Abello, personal fees from Adiga, Biomay, Allergopharma, Anergis, Allergy Therapeutics. TH reports personal fees from GSK, Mundipharma, Orion Pharma. SH reports other from ALK‐Abelló, other from ALK‐Abelló. EH reports personal fees from Sanofi, Novartis, GSK, AstraZeneca, Circassia, Nestlè Purina. JCI reports personal fees from Faes Farma, Laboratorios Casasco Argentina, Abbott de Ecuador, EuroFarma Argentina. MJ reports personal fees from ALK‐Abello, Allergopharma, Stallergenes, Anergis, Allergy Therapeutics, Circassia, Leti, Biomay, HAL, during the conduct of the study; personal fees from Astra‐Zeneka, GSK, Novartis, Teva, Vectura, UCB, Takeda, Roche, Janssen, Medimmune, Chiesi,. LK reports grants and personal fees from Allergopharma, MEDA/Mylan, LETI Pharma, Sanofi, grants from Stallergenes, Quintiles, ASIT biotech, grants from ALK Abelló, Lofarma, AstraZeneca, GSK, Inmunotk, personal fees from Allergy Therapeut., HAL Allergie, Cassella med; and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO‐BV, GPA, EAACI. PK reports personal fees from Adamed, Berlin Chemie Menarini, Boehringer Ingelheim, AstraZeneca, Lekam, Novartis, Polpharma, GSK, Polpharma, Sanofi, teva. VK reports other from GSK, non‐financial support from Mylan, AstraZeneca, Dimuna, Norameda. SL reports personal fees from DBV, Sanofi Aventis, Allergopharma, ALK, Nutricia, Bencard. EM reports personal fees from Sanofi, Novartis, AstraZeneca and Chiesi. JM reports personal fees and other from SANOFI‐GENZYME & REGENERON, NOVARTIS, ALLAKOS, MITSUBISHI‐TANABE, MENARINI, UCB, ASTRAZENECA, GSK, MSD, grants and personal fees from MYLAN‐MEDA Pharma, URIACH Group. MO reports personal fees from Hycor Diagnostics, Thermo Fisher Phadia. YO reports personal fees from Torii Pharmaceutical Co., Ltd., Shionogi Pharmaceutical Co.,Ltd. OP received research grants from Inmunotek S.L., Novartis and MINECO and has received fees for giving scientific lectures or participation in Advisory Boards from: Allergy Therapeutics, Amgen, AstraZeneca, Diater, GlaxoSmithKline, S.A, Inmunotek S.L, Novartis, Sanofi‐Genzyme and Stallergenes. NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. OP reports grants and personal fees from ALK‐Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools S.A., Laboratorios LETI/LETI Pharma, Anergis S.A., Glaxo Smith Kline, grants from Biomay, Circassia, Pohl‐Boskamp, Inmunotek S.L., personal fees from MEDA Pharma/MYLAN, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, Astellas Pharma Global, EUFOREA, ROXALL Medizin, Novartis, Sanofi‐Aventis and Sanofi‐Genzyme, Med Update Europe GmbH, streamedup! GmbH, John Wiley and Sons, AS. DPreports grants and personal fees from GlaxoSmithKline, personal fees from Menarini, Pliva, Belupo, AbbVie, Novartis, MSD, Chiesi, Revenio, personal fees and non‐financial support from Boehringer Ingelheim, non‐financial support from Philips. MR is on the Advisory board‐ A. Menarini ‐ Speaker ‐ Astra Zeneca, Novartis, Sanofi, Mylan. FSRreports speaker and advisory fees from AstraZeneca, Novartis, Sanofi, GSK, Teva and Lusomedicamenta. GR reports payment to his Institution from Allergo Pharma. BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. JS reports grants and personal fees from Sanofi, personal fees from GSK, Novartis, Astra Zeneca, Mundipharma, Faes Farma. GS reports personal fees from ALK, and leds on the BSACI Rhinitis Guidelines and lead for EUFOREA on Allergic Rhinitis. PSG reports personal fees from Allergopharma, ALK, grants from Bencard, grants and personal fees from Stallergenes. JS reports personal fees from Mylan, F2F events. ATB reports grants and personal fees from Teva, AstraZeneca, GSK Sanofi, Mundipharma, personal fees from Bial, Novartis. MJTreports grants from European Commission, SEAIC, ISCIII, personal fees from Diater laboratory, Leti laboratory, Aimmune Therapeutics. MW reports personal fees from ALK‐Abello, Allergopharma, AstraZeneca, Bencard, Genzyme, GlaxoSmithKline, HAL Allergy, LETI, Meda Pharma, Novartis, Sanofi, Stallergenes, Teva. DW reports other from Optinose, ALK, Sanofi; past Co‐Chair of the Joint Task Force on Practice Parameters of the AAAAI and ACAAI. Second author of a recently published practice parameter on Rhinitis. MW reports other from Aralez (Medexus), Pediapharm, Pfizer, Astra Zeneca, GSK, Alk. MZ reports personal fees from Takeda. TZ reports and Organizational affiliations: Commitee member: WHO‐Initiative “Allergic Rhinitis and Its Impact on Asthma” (ARIA). Member of the Board: German Society for Allergy and Clinical Immunology (DGAKI). Head: European Centre for Allergy Research Foundation (ECARF). Secretary General: Global Allergy and Asthma European Network (GA2LEN). Member: Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO). FIGURE 1Countries with Pocket Guide membersFIGURE 2Proposed Flow of Precision Medicine approach in allergic diseases. *examples of exceptions: Thunderstorm‐induced asthma, patient with moderate rhinitis and severe asthma during pollen seasonFIGURE 3Treatment algorithm using visual analogue scale (VAS) for adolescents and adults AIT, allergen immunotherapy; VAS, visual analogue scale.FIGURE 4Algorithm for AIT in asthma

Figures

FIGURE 1
FIGURE 1
Countries with Pocket Guide members
FIGURE 2
FIGURE 2
Proposed Flow of Precision Medicine approach in allergic diseases. *examples of exceptions: Thunderstorm‐induced asthma, patient with moderate rhinitis and severe asthma during pollen season
FIGURE 3
FIGURE 3
Treatment algorithm using visual analogue scale (VAS) for adolescents and adults AIT, allergen immunotherapy; VAS, visual analogue scale.
FIGURE 4
FIGURE 4
Algorithm for AIT in asthma
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