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. 2021 May 24;7(5):e07110.
doi: 10.1016/j.heliyon.2021.e07110. eCollection 2021 May.

A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women

Rosane de Fátima Zanirato Lizarelli  1 , Clovis Grecco  2 , Simone Cecilio Hallak Regalo  3 , Fernando Luis Esteban Florez  4 , Vanderlei Salvador Bagnato  1
Affiliations

A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women

Rosane de Fátima Zanirato Lizarelli et al. Heliyon. .

Abstract

The present pilot study had the objective to determine the effects of transcutaneous and transmucosal laser irradiation on arterial blood pressure (ABP), glucose (Glu) triglycerides (Tg), total cholesterol (Ch), high-density level cholesterol (HDL) and low-density cholesterol (LDL) immediately after treatment (T0) and after 30 (T30) and 60 (T60) days. Patients (n = 36) were selected and randomly distributed into 6 groups (n = 6/group; [G1] negative control, [G2] radial artery transcutaneous laser irradiation [G3] radial artery transcutaneous irradiation, [G4] transmucosal sublingual irradiation, [G5] transmucosal intra-nasal irradiation and [G6] extended radial artery transcutaneous irradiation). Blood exams were performed at T0, T30 and T60. Systolic and diastolic pressure results have indicated that patients' pressures ranged from 90 mmHg (P22, T30, G4) to 189 mmHg (P16, T0, G3) and 54 mmHg (P21, T60, G4) to 175 mmHg (P16, T30, G3). Levels of Glu at T30 and T60 varied from 5.53% (G1) to -5.78% (G6) and 1.21 (G2) to -8.69 (G6), respectively. Data was statistically assessed for normality and homogeneity of variances using the F-statistic and Bartlett's tests. Significant differences were determined using One-Way ANOVA and Fischer post hoc tests. Results indicated that treatments investigated can be safely used as an adjunct method to regulate blood pressure, glucose, triglycerides and cholesterol.

Keywords: Blood pressure; Cholesterol; Glucose; Infrared; Low intensity level laser; Transcutaneous; Transmucosal; Triglycerides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Radial artery transcutaneous irradiation using (A) pen-shaped dual-wavelength low intensity level laser (Laser Duo, MMO, Brazil; 660 nm and 808 nm, 100 mW/each, spot size = 0.03 cm2) and a prototype bracelet-shaped single-wavelength low intensity level laser (660 nm, 100 mW, spot size = 4.0 cm2; LAT, São Carlos Physics Institute).
Figure 2
Figure 2
(A) Transmucosal sublingual irradiation and (B) transmucosal intra-nasal irradiation using pen-shaped dual-wavelength low intensity level laser (Laser Duo, MMO, Brazil; 660 nm and 808 nm, 100 mW/each, spot size = 0.03 cm2).
Figure 3
Figure 3
Temporal evolution (T0, T30 and T60) of (A) systolic and (B) diastolic blood pressures for patients 1–36.
Figure 4
Figure 4
Results of the glucose variation (ΔGlu [%]) after thirty (T30) and sixty days (T60) of treatment.
Figure 5
Figure 5
Results of the triglycerides variation (ΔTg [%]) after thirty (T30) and sixty days (T60) of treatment.
Figure 6
Figure 6
Results of the total cholesterol variation (ΔCh [%]) after thirty (T30) and sixty days (T60) of treatment.
Figure 7
Figure 7
Results of the high-density cholesterol variation (ΔHDL [%]) after thirty (T30) and sixty days (T60) of treatment.
Figure 8
Figure 8
Results of the low-density cholesterol variation (ΔLDL [%]) after thirty (T30) and sixty days (T60) of treatment.
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References

    1. (IQWiG), I. f. Q. a. E. i. H. C. 2010. What Is an Inflammation?https://www.ncbi.nlm.nih.gov/books/NBK279298/
    1. Aminov R.I. A brief history of the antibiotic era: lessons learned and challenges for the future. Front. Microbiol. 2010;1 134-134. - PMC - PubMed
    1. Scully C. Drug effects on salivary glands: dry mouth. Oral Dis. 2003;9:165–176. - PubMed
    1. Visvanathan V., Nix P. Managing the patient presenting with xerostomia: a review. Int. J. Clin. Pract. 2010;64:404–407. - PubMed
    1. Tayem Y.I. Non-steroidal anti-inflammatory drugs and antibiotics prescription trends at a central west bank hospital. Sultan Qaboos Univ. Med. J. 2013;13:567–573. - PMC - PubMed