Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;52(1):137-143.
doi: 10.1007/s00595-021-02319-0. Epub 2021 Jun 16.

Outcomes of lung cancer surgery for patients with interstitial pneumonia and coronary disease

Mariko Fukui  1 , Kazuya Takamochi  2 , Kazuhiro Suzuki  3 , Katsutoshi Ando  4 , Takeshi Matsunaga  2 , Aritoshi Hattori  2 , Shiaki Oh  2 , Kenji Suzuki  2
Affiliations

Outcomes of lung cancer surgery for patients with interstitial pneumonia and coronary disease

Mariko Fukui et al. Surg Today. 2022 Jan.

Abstract

Purpose: To evaluate the surgical outcomes of lung cancer patients with idiopathic interstitial pneumonia (IIP) and/or coronary artery disease (CAD).

Methods: The subjects of this retrospective study were 2830 patients who underwent surgical resection for lung cancer between 2009 and 2018. Seventy-one patients (2.6%) had both IIP and CAD (FC group). The remaining patients were divided into those with IIP only (group F), those with CAD only (group C), and those without IIP or CAD (group N). We compared mortality and overall survival (OS) among the groups.

Results: The 90-day mortality and OS were poorer in group FC than in groups C and N, but equivalent to those in group F. Multivariate analyses revealed that IIP (odds ratio [OR] 3.163; p = 0.001) and emphysema (2.588; p = 0.009) were predictors of 90-day mortality. IIP (OR 2.991, p < 0.001), diabetes (OR 1.241, p = 0.043), and a history of other cancers (OR 1.347, p = 0.011) were all predictors of OS.

Conclusions: Short-term and long-term mortality after lung cancer surgery were not dependent on coexistent CAD but were related to IIP. Thus, computed tomography (CT) should be done preoperatively to check for IIP, which is a risk factor for surgical mortality.

Keywords: Coronary artery disease; Idiopathic interstitial pneumonias; Lung cancer; Mortality; Surgery.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Okami J, Shintani Y, Okumura M, Ito H, Ohtsuka T, Toyooka S, et al. Demographics, safety and quality, and prognostic information in both the seventh and eighth editions of the TNM classification in 18,973 surgical cases of the Japanese Joint Committee of Lung Cancer registry database in 2010. J Thorac Oncol. 2019;14(2):212–22. - DOI
    1. Boffa DJ, Allen MS, Grab JD, Gaissert HA, Harpole DH, Wright CD. Data from the Society of thoracic surgeons general thoracic surgery database: the surgical management of primary lung tumors. J Thorac Cardiovasc Surg. 2008;135(2):247–54. - DOI
    1. Falcoz PE, Conti M, Brouchet L, Chocron S, Puyraveau M, Mercier M, et al. The thoracic surgery scoring system (Thoracoscore): risk model for in-hospital death in 15,183 patients requiring thoracic surgery. J Thorac Cardiovasc Surg. 2007;133(2):325–32. - DOI
    1. Sakata R, Fujii Y, Kuwano H. Thoracic and cardiovascular surgery in Japan during 2008: annual report by The Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg. 2010;58(7):356–83. - DOI
    1. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824. - DOI

MeSH terms

LinkOut - more resources