Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;26(24):2100452.
doi: 10.2807/1560-7917.ES.2021.26.24.2100452.

Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021

Clara Mazagatos  1 , Susana Monge  2 , Carmen Olmedo  3 , Lorena Vega  1 , Pilar Gallego  1 , Elisa Martín-Merino  4 , María José Sierra  2 , Aurora Limia  3 , Amparo Larrauri  1 ; Working Group for the surveillance and control of COVID-19 in Spain  5 ; Working group for the surveillance and control of COVID-19 in Spain
Collaborators, Affiliations

Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021

Clara Mazagatos et al. Euro Surveill. 2021 Jun.

Abstract

Residents in long-term care facilities (LTCF) experienced a large morbidity and mortality during the COVID-19 pandemic in Spain and were prioritised for early COVID-19 vaccination. We used the screening method and population-based data sources to obtain estimates of mRNA COVID-19 vaccine effectiveness for elderly LTCF residents. The estimates were 71% (95% CI: 56-82%), 88% (95% CI: 75-95%), and 97% (95% CI: 92-99%), against SARS-CoV-2 infections (symptomatic and asymptomatic), and COVID-19 hospitalisations and deaths, respectively.

Keywords: COVID-19; LTCF; screening; surveillance; vaccination.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Weekly number of (A) COVID-19 cases and (B) elderly long-term care facilities residents by COVID-19 vaccination status, Spain, weeks 53 2020 to 13 2021
Figure 2
Figure 2
Vaccine effectiveness against SARS-CoV-2 infections, hospitalisations and deaths in fully vaccinateda elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021 (n = 8,379)
See this image and copyright information in PMC

References

    1. Instituto de Mayores y Servicios Sociales (IMSERSO). Actualización no 6. Enfermedad por coronavirus (COVID-19) en Centros Residenciales. [Update No. 6. Coronavirus (COVID-19) in Residential Centers]. Madrid: IMERSO; 2021. Spanish. Available from: https://www.imserso.es/InterPresent1/groups/imserso/documents/binario/in...
    1. Ministerio de Sanidad, Gobierno de España. Informe de Gestión Integral de la Vacunación COVID-19, Fecha del informe 12 de abril de 2021. [COVID-19 Vaccination Management Report, Ministry of Health, Government of Spain]. Madrid: Ministerio de Sanidad; 2021. Spanish. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual...
    1. Farrington CP. Estimation of vaccine effectiveness using the screening method. Int J Epidemiol. 1993;22(4):742-6. 10.1093/ije/22.4.742 - DOI - PubMed
    1. Remschmidt C, Rieck T, Bödeker B, Wichmann O. Application of the screening method to monitor influenza vaccine effectiveness among the elderly in Germany. BMC Infect Dis. 2015;15(1):137. 10.1186/s12879-015-0882-3 - DOI - PMC - PubMed
    1. Mazagatos C, Delgado-Sanz C, Oliva J, Gherasim A, Larrauri A, Spanish Influenza Surveillance System . Exploring the risk of severe outcomes and the role of seasonal influenza vaccination in pregnant women hospitalized with confirmed influenza, Spain, 2010/11-2015/16. PLoS One. 2018;13(8):e0200934. 10.1371/journal.pone.0200934 - DOI - PMC - PubMed