Beware of Histiocytes: Whipple Adenopathy and its Mimics

Abstract

Histiocytic proliferations are heterogeneous lesions with distinct pathogenic and clinical-pathological features. While many of these conditions are nonspecific immune responses to variable causes, a minority of them is associated with specific etiological factors and unique clinical-pathological pictures. By presenting a rare case of Whipple adenopathy, we address the peculiar histological features of this condition and the differential diagnosis of nodal histiocytosis in general.

Keywords: Whipple disease; hematopathology; histiocytosis; infectious disease; lymphadenopathy.