Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 30;41(7):BSR20204102.
doi: 10.1042/BSR20204102.

Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon

Jasna Letícia Pinto Paz  1 , Maria do Perpétuo Socorro Corrêa Amador Silvestre  2 , Letícia Siqueira Moura  2 , Ismari Perini Furlaneto  3 , Yan Corrêa Rodrigues  1   2 , Karla Valéria Batista Lima  1   2 , Luana Nepomuceno Gondim Costa Lima  1   2   4
Affiliations

Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon

Jasna Letícia Pinto Paz et al. Biosci Rep. .

Abstract

The transmission and evolution of leprosy depends on several aspects, including immunological and genetic factors of the host, as well as genetic factors of Mycobacterium leprae. The present study evaluated the association of single nucleotide polymorphisms (SNPs) on the FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) regions of the vitamin D receptor (VDR) gene with leprosy. A total of 405 individuals were evaluated, composed by groups of 100 multibacillary (MB) and 57 paucibacillary (PB) patients, and 248 healthy contacts. Blood samples were collected from patients and contacts. The genotyping was performed by sequencing of the interest regions. The alleles of the studied SNPs, and SNP FokI genotypes, were not associated with leprosy. For the SNP on TaqI region, the relationship between the tt genotype, and for the SNP ApaI, the AA genotype, revealed an association with susceptibility to MB form, while Aa genotype with protection. The extended genotypes AaTT and AaTt of ApaI and TaqI were associated with protection against MB form. Further studies analyzing the expression of the VDR gene and the correlation with its SNPs might help to clarify the role of polymorphisms on the immune response in leprosy.

Keywords: Leprosy; genotype; vitamin D receptor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Similar articles

See all similar articles

Cited by

References

    1. Uaska Sartori P.V., Penna G.O., Bührer-Sékula S., Pontes M.A.A., Gonçalves H.S., Cruz R.et al. . (2020) Human genetic susceptibility of leprosy recurrence. Sci. Rep. 10, 1–5 10.1038/s41598-020-58079-3 - DOI - PMC - PubMed
    1. Mi Z., Liu H. and Zhang F. (2020) Advances in the immunology and genetics of leprosy. Front. Immunol. 11, 1–15 10.3389/fimmu.2020.00567 - DOI - PMC - PubMed
    1. Gaschignard J., Grant A.V., van Thuc N., Orlova M., Cobat A., Huong N.T.et al. . (2016) Pauci- and multibacillary leprosy: two distinct, genetically neglected diseases. PLoS Negl. Trop. Dis. 10, 1–20 10.1371/journal.pntd.0004345 - DOI - PMC - PubMed
    1. Ministério da Saúde. Brasil, de Vigilância em Saúde Secretaria, (2020) Hanseníase. Boletim Epidemiológico http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-de-hansenia...
    1. Tabra S.A.A., Abdelnabi H.H., Darwish N.F.M., El-Barbary A.M., AbdelGhafar M.T. and Abu-Zaid M.H. (2020) Juvenile lupus and serum vitamin D levels: a cross-sectional study. Lupus 29, 1752–1758 10.1177/0961203320957721 - DOI - PubMed

Publication types