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. 2022 Jan;269(1):44-46.
doi: 10.1007/s00415-021-10655-x. Epub 2021 Jun 18.

Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex

Jacques Hugon  1   2 , Eva-Flore Msika  3 , Mathieu Queneau  4 , Karim Farid  5 , Claire Paquet  6
Affiliations

Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex

Jacques Hugon et al. J Neurol. 2022 Jan.

Abstract

Many patients who have suffered from acute COVID infections have long-lasting symptoms affecting several organs including the brain. This long COVID status can include "brain fog" and cognitive deficits that can disturb activities of daily living and can delay complete recovery. Here, we report two cases of neurological long COVID with abnormal FDG PET findings marked by hypometabolic regions of the cingulate cortex.

Keywords: Cingulate cortex; Cognitive involvement; Long COVID.

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Conflict of interest statement

The authors declare no conflict of interests regarding this work.

Figures

Fig. 1
Fig. 1
The cerebral Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) of patients 1 and 2. In patient 1, the posterior cingulate cortex and the precuneus are the most hypometabolic regions. In patient 2, anterior and posterior cingulate cortex are involved (more than 2SD)
Fig. 2
Fig. 2
Brain MRI of patient 1 (left panel and patient 2 (right panel). Both MRI were found normal
See this image and copyright information in PMC

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