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. 2022 Jan;54(1):209-215.
doi: 10.1007/s11255-021-02916-5. Epub 2021 Jun 18.

Efficacy of dexmedetomidine on peritoneal dialysis catheter insertion

Takashin Nakayama  1 , Kiyotaka Uchiyama  2 , Kohkichi Morimoto  3 , Naoki Washida  1   4 , Takahiro Kasai  4 , Ran Nakamichi  1 , Ei Kusahana  1 , Shu Wakino  1 , Hiroshi Itoh  1
Affiliations

Efficacy of dexmedetomidine on peritoneal dialysis catheter insertion

Takashin Nakayama et al. Int Urol Nephrol. 2022 Jan.

Abstract

Purpose: Dexmedetomidine (DEX) is a sedative agent with minimal respiratory and hemodynamic effects. The present study aimed to evaluate its effectiveness in peritoneal dialysis (PD) catheter insertion.

Methods: This single-center retrospective study included patients who underwent PD catheter insertion under spinal anesthesia in our hospital between January 2016 and December 2020. Patients were divided into the DEX and non-DEX groups according the use of DEX. After 1:1 propensity score matching to adjust for age, sex, body mass index, mean blood pressure (BP), and Charlson comorbidity index, we compared operation-related outcomes, including peak numerical rating scale (NRS), occurrence of nausea, vital signs, or operative time between the two groups.

Results: Of a total of 44 patients, 9 patients received DEX, and 35 did not. After propensity score matching, each group consisted of 8 patients. Peak NRS was significantly lower (P = 0.003) in the DEX group compared with the non-DEX group. Maximum mean BP during the operation was also significantly lower in the DEX group compared with the non-DEX group (P = 0.020), with no significant differences in minimum mean BP between the two groups (P = 0.831). The DEX group showed a trend of shortened operative time (P = 0.068). There were no significant differences in the occurrence of nausea (P = 1.000). Moreover, there was no clinically important adverse event associated with use of DEX.

Conclusion: The use of DEX in PD catheter insertion under spinal anesthesia could safely improve operative analgesia.

Keywords: Dexmedetomidine; Peritoneal dialysis; Peritoneal dialysis catheter insertion; Spinal anesthesia.

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