Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jun 17;28(6):741-742.
doi: 10.1016/j.chembiol.2021.05.013.

MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Matthew Dodson  1 , Annadurai Anandhan  1 , Donna D Zhang  2
Affiliations
Free article
Comment

MGST1, a new soldier of NRF2 in the battle against ferroptotic death

Matthew Dodson et al. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Kuang et al. (2021) identify microsomal glutathione-S-transferase 1 (MGST1) as an NRF2 target gene that suppresses ferroptosis in pancreatic cancer cells. Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production. Thus, MGST1 could represent a viable therapeutic target for treating pancreatic cancer.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Substances

LinkOut - more resources