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Comment
. 2021 Jun 17;81(12):2504-2506.
doi: 10.1016/j.molcel.2021.05.029.

Oncogenic signaling of RTK fusions becomes more granular

Matthew J Cuneo  1 , Tanja Mittag  2
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Comment

Oncogenic signaling of RTK fusions becomes more granular

Matthew J Cuneo et al. Mol Cell. .
Free article

Abstract

A spectrum of cancers arises from chromosomal translocations that fuse receptor tyrosine kinase domains to oligomerization domains from unrelated proteins. Tulpule et al. (2021) demonstrate that fusion proteins with the ability to assemble higher-order cytoplasmic protein granules can activate RAS signaling in a lipid membrane-independent manner.

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Conflict of interest statement

Declaration of interests T.M. is a consultant for and shareholder of Faze Medicines. T.M. is a member of the Molecular Cell advisory board.

Comment on

  • Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.
    Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. Tulpule A, et al. Cell. 2021 May 13;184(10):2649-2664.e18. doi: 10.1016/j.cell.2021.03.031. Epub 2021 Apr 12. Cell. 2021. PMID: 33848463 Free PMC article.

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