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Meta-Analysis
. 2021 Jun 19;21(1):125.
doi: 10.1186/s12902-021-00789-4.

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

Nader Salari  1 , Niloufar Darvishi  2 , Kamran Mansouri  3 , Hooman Ghasemi  2 , Melika Hosseinian-Far  4 , Fateme Darvishi  2 , Masoud Mohammadi  5
Affiliations
Meta-Analysis

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

Nader Salari et al. BMC Endocr Disord. .

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to be the leading cause of chronic liver disease worldwide. This study aims to systematically review and meta-analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver.

Methods: Following a systematic review and meta-analysis method, articles without any time limitation, were extracted from SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed and ScienceDirect international databases. Random effects model was used for analysis, and heterogeneity of studies was investigated considering the I2 index and using Comprehensive Meta-Analysis software.

Results: The odds ratio of CC genotype in patients with non-alcoholic fatty liver demonstrates the protective effect of CC genotype with the ratio of 0.52, whereas CG genotype presents an increasing effect of CG genotype with the ratio of 0.19, and GG genotype also showed an increasing effect of GG genotype with the ratio of 1.05. Moreover, CG + GG genotypes as a single group demostrated an odds rartio of 0.88.

Conclusion: This meta-analysis highlights that people with CC genotype has 52% lower chance of developing non-alcoholic fatty liver disease, and those with CG genotype had 19% higher risk of developing non-alcoholic fatty liver. Those with GG genotype were 105% more likely to develop non-alcoholic fatty liver than others. Moreover, those present in a population with CG + GG genotypes were 88% more likely to have non-alcoholic fatty liver disease.

Keywords: Gene; NAFLD; Non-alcoholic fatty liver; PNPLA3; Polymorphism.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram for the processes followed for includign studies in this systematic review and meta-analysis
Fig. 2
Fig. 2
Funnel plot (A) and Overall forest plot of CC Genotype in Patients with Non-Alcoholic Fatty Liver Based on Random Model (B)
Fig. 3
Fig. 3
Funnel plot (A) and Overall forest plot of CG Genotype in Patients with Non-Alcoholic Fatty Liver Based on Random Model (B)
Fig. 4
Fig. 4
Funnel plot (A) and Overall forest plot of GG Genotype in Patients with Non-Alcoholic Fatty Liver Based on Random Model (B)
Fig. 5
Fig. 5
Funnel plot (A) and Overall forest plot of CG + GG Genotype in Patients with Non-Alcoholic Fatty Liver Based on Random Model (B)
See this image and copyright information in PMC

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