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. 2021 Dec:82:100987.
doi: 10.1016/j.mam.2021.100987. Epub 2021 Jun 16.

Non-canonical functions of autophagy proteins in immunity and infection

Christian Münz  1
Affiliations
Free article

Non-canonical functions of autophagy proteins in immunity and infection

Christian Münz. Mol Aspects Med. 2021 Dec.
Free article

Abstract

The molecular machinery of macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes, remodels membranes by lipid phosphorylation and conjugation of LC3 and GABARAP proteins. In recent year it has become clear that these membrane modifications also regulate endo- and exocytosis. Here I will discuss recent evidence of how such non-canonical functions of the macroautophagy machinery with its autophagy related gene (atg) products influences infectious viral particle secretion, inflammation, and MHC restricted antigen presentation. Especially LC3-Associated Phagocytosis and ATG supported exocytosis will be high-lighted during immunity and infection.

Keywords: Exocytosis; Inflammation; LC3-Associated phagocytosis (LAP); MHC restricted Antigen presentation; Viral envelope.

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