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Review
. 2021 Oct;160(4):1232-1240.
doi: 10.1016/j.chest.2021.06.017. Epub 2021 Jun 17.

Pulmonary Complications in Cystic Fibrosis: Past, Present, and Future: Adult Cystic Fibrosis Series

Christina M Mingora  1 , Patrick A Flume  2
Affiliations
Review

Pulmonary Complications in Cystic Fibrosis: Past, Present, and Future: Adult Cystic Fibrosis Series

Christina M Mingora et al. Chest. 2021 Oct.

Abstract

1Cystic fibrosis (CF) is an autosomal recessive genetic condition with multisystemic disease manifestations, the most prominent of which occur in the respiratory system. Despite significant developments in disease understanding and therapeutics, each contributing to improved lung function and survival in patients with CF, several pulmonary complications, including pneumothorax, massive hemoptysis, and respiratory failure, continue to occur. In this review, we briefly describe each of these complications and their management and discuss how they impact the care and disease trajectory of individuals in whom they occur. Finally, we discuss the evolving role that palliative care and CF transmembrane conductance regular modulator therapies play in the natural disease course and care of patients with CF.

Keywords: CFTR modulator; complications; cystic fibrosis; hemoptysis; palliative care; pneumothorax; pulmonary hypertension; respiratory failure.

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References

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