Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound?

doi:10.1016/j.jinf.2021.06.015

Comment

. 2021 Aug;83(2):e6-e8.

doi: 10.1016/j.jinf.2021.06.015. Epub 2021 Jun 18.

Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound?

Maaike Buskermolen¹, Karlijn Te Paske², Janko van Beek³, Titia Kortbeek⁴, Hannelore Götz⁵, Ewout Fanoy⁶, Sabiena Feenstra⁴, Jan Hendrik Richardus⁷, Albert Vollaard⁴

Affiliations

¹ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands. Electronic address: m.buskermolen@rotterdam.nl.
² Department of Infectious Disease Control, Municipal Public Health Service Utrecht, Utrecht, Netherlands.
³ Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
⁴ Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
⁵ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
⁶ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands.
⁷ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

PMID: 34147529
PMCID: PMC8236092
DOI: 10.1016/j.jinf.2021.06.015

Comment

Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound?

Maaike Buskermolen et al. J Infect. 2021 Aug.

. 2021 Aug;83(2):e6-e8.

doi: 10.1016/j.jinf.2021.06.015. Epub 2021 Jun 18.

Authors

Maaike Buskermolen¹, Karlijn Te Paske², Janko van Beek³, Titia Kortbeek⁴, Hannelore Götz⁵, Ewout Fanoy⁶, Sabiena Feenstra⁴, Jan Hendrik Richardus⁷, Albert Vollaard⁴

Affiliations

¹ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands. Electronic address: m.buskermolen@rotterdam.nl.
² Department of Infectious Disease Control, Municipal Public Health Service Utrecht, Utrecht, Netherlands.
³ Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
⁴ Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
⁵ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
⁶ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands.
⁷ Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

PMID: 34147529
PMCID: PMC8236092
DOI: 10.1016/j.jinf.2021.06.015

No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest None of the authors has any conflict of interest to declare regarding this subject. This work had no financial support.

Comment on

Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?
Gousseff M, Penot P, Gallay L, Batisse D, Benech N, Bouiller K, Collarino R, Conrad A, Slama D, Joseph C, Lemaignen A, Lescure FX, Levy B, Mahevas M, Pozzetto B, Vignier N, Wyplosz B, Salmon D, Goehringer F, Botelho-Nevers E; in behalf of the COCOREC study group. Gousseff M, et al. J Infect. 2020 Nov;81(5):816-846. doi: 10.1016/j.jinf.2020.06.073. Epub 2020 Jun 30. J Infect. 2020. PMID: 32619697 Free PMC article.

Cited by

Understanding the neurological implications of acute and long COVID using brain organoids.
García-González L, Martí-Sarrias A, Puertas MC, Bayón-Gil Á, Resa-Infante P, Martinez-Picado J, Navarro A, Acosta S. García-González L, et al. Dis Model Mech. 2023 Jul 1;16(7):dmm050049. doi: 10.1242/dmm.050049. Epub 2023 Jul 17. Dis Model Mech. 2023. PMID: 37458167 Free PMC article. Review.
Viral and Symptom Rebound in Untreated COVID-19 Infection.
Deo R, Choudhary MC, Moser C, Ritz J, Daar ES, Wohl DA, Greninger AL, Eron JJ, Currier JS, Hughes MD, Smith DM, Chew KW, Li JZ; ACTIV-2/A5401 Study Team. Deo R, et al. medRxiv [Preprint]. 2022 Aug 2:2022.08.01.22278278. doi: 10.1101/2022.08.01.22278278. medRxiv. 2022. PMID: 35982660 Free PMC article. Preprint.
A COVID-19 Infection Model Considering the Factors of Environmental Vectors and Re-Positives and Its Application to Data Fitting in Japan and Italy.
Dong S, Lv J, Ma W, Pradeep BGSA. Dong S, et al. Viruses. 2023 May 19;15(5):1201. doi: 10.3390/v15051201. Viruses. 2023. PMID: 37243286 Free PMC article.
Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection.
Deo R, Choudhary MC, Moser C, Ritz J, Daar ES, Wohl DA, Greninger AL, Eron JJ, Currier JS, Hughes MD, Smith DM, Chew KW, Li JZ; ACTIV-2/A5401 Study Team. Deo R, et al. Ann Intern Med. 2023 Mar;176(3):348-354. doi: 10.7326/M22-2381. Epub 2023 Feb 21. Ann Intern Med. 2023. PMID: 36802755 Free PMC article.
Transmission dynamics of COVID-19 pandemic with combined effects of relapse, reinfection and environmental contribution: A modeling analysis.
Musa SS, Yusuf A, Zhao S, Abdullahi ZU, Abu-Odah H, Saad FT, Adamu L, He D. Musa SS, et al. Results Phys. 2022 Jul;38:105653. doi: 10.1016/j.rinp.2022.105653. Epub 2022 May 29. Results Phys. 2022. PMID: 35664991 Free PMC article.

See all "Cited by" articles

References

1. Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020;81(5):816–846. - PMC - PubMed
1. Yahav D., Yelin D., Eckerle I., Eberhardt C.S., Wang J., Cao B. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. Clin Microbiol Infect. 2021;27(3):315–318. - PMC - PubMed
1. Findings from investigation and analysis of re-positive cases. Korea Cent Dis Control Prevent. 2020
1. Lu J., Peng J., Xiong Q., Liu Z., Lin H., Tan X. Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR. E Bio Med. 2020;59 - PMC - PubMed
1. Ren X., Ren X., Lou J., Wang Y., Huang Q., Shi Y. A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR. E Clin Med. 2021;34 - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020;81(5):816–846. - PMC - PubMed

[2] Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020;81(5):816–846. - PMC - PubMed

[3] Yahav D., Yelin D., Eckerle I., Eberhardt C.S., Wang J., Cao B. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. Clin Microbiol Infect. 2021;27(3):315–318. - PMC - PubMed

[4] Yahav D., Yelin D., Eckerle I., Eberhardt C.S., Wang J., Cao B. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. Clin Microbiol Infect. 2021;27(3):315–318. - PMC - PubMed

[5] Findings from investigation and analysis of re-positive cases. Korea Cent Dis Control Prevent. 2020

[6] Findings from investigation and analysis of re-positive cases. Korea Cent Dis Control Prevent. 2020

[7] Lu J., Peng J., Xiong Q., Liu Z., Lin H., Tan X. Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR. E Bio Med. 2020;59 - PMC - PubMed

[8] Lu J., Peng J., Xiong Q., Liu Z., Lin H., Tan X. Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR. E Bio Med. 2020;59 - PMC - PubMed

[9] Ren X., Ren X., Lou J., Wang Y., Huang Q., Shi Y. A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR. E Clin Med. 2021;34 - PMC - PubMed

[10] Ren X., Ren X., Lou J., Wang Y., Huang Q., Shi Y. A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR. E Clin Med. 2021;34 - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound?

Affiliations

Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound?

Authors

Affiliations

Conflict of interest statement

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical