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Review
. 2021 Oct 1:239:118262.
doi: 10.1016/j.neuroimage.2021.118262. Epub 2021 Jun 18.

Meaningful associations in the adolescent brain cognitive development study

Anthony Steven Dick  1 , Daniel A Lopez  2 , Ashley L Watts  3 , Steven Heeringa  4 , Chase Reuter  5 , Hauke Bartsch  6 , Chun Chieh Fan  7 , David N Kennedy  8 , Clare Palmer  9 , Andrew Marshall  10 , Frank Haist  11 , Samuel Hawes  1 , Thomas E Nichols  12 , Deanna M Barch  13 , Terry L Jernigan  8 , Hugh Garavan  14 , Steven Grant  15 , Vani Pariyadath  15 , Elizabeth Hoffman  16 , Michael Neale  17 , Elizabeth A Stuart  18 , Martin P Paulus  19 , Kenneth J Sher  3 , Wesley K Thompson  20
Affiliations
Review

Meaningful associations in the adolescent brain cognitive development study

Anthony Steven Dick et al. Neuroimage. .

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

Keywords: Adolescent brain cognitive development study; Covariate Adjustments; Effect Sizes; Genetics; Hypothesis testing; Population neuroscience; Reproducibility.

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Figures

Figure 1:
Figure 1:. ABCD Study Assessments for NDA 2.0.1 Release Data
Figure 2:
Figure 2:. ABCD Data Collection and NDA Release Schedule
Figure 3:
Figure 3:. Power vs. Sample Size for Pearson |r|
Figure 4:
Figure 4:. Association Between Obesity and Nucleus Accumbens RSI N0
Figure 5:
Figure 5:. Models for Measurement Contamination, Spuriousness, and Mediation
Note. This figure is adapted from Spector and Brannick (2011). Lowercase letters refer to observed indicators (in boxes), whereas uppercase letters refer to latent indicators (constructs, in circles).
Figure 6:
Figure 6:. The association between parental history of alcohol problems and CBCL Externalizing
See this image and copyright information in PMC

References

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