Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 19;16(1):98.
doi: 10.1007/s11657-021-00947-0.

Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data

Hyo Geun Choi  1   2 , Yong Joon Suh  3 , Jung Woo Lee  4 , Chan Yang Min  1 , Dae Myoung Yoo  1 , Suk Woo Lee  5   6
Affiliations

Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data

Hyo Geun Choi et al. Arch Osteoporos. .

Abstract

We performed a nationwide, population-based cohort study to evaluate the risk of osteoporosis and osteoporotic fracture in patients with breast cancer using the data from Korean Genome and Epidemiology Study (KoGES) and concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, regardless of age.

Purpose: This study aimed to evaluate the association between breast cancer and the occurrence of osteoporosis and osteoporotic fracture using data from the Korean Genome and Epidemiology Study (KoGES).

Methods: Using the national KoGES health examinee (HEXA) data consisting of data from urban resident participants ≥ 40 years old, we extracted data for patients with breast cancer (n = 1080) and for control participants (n = 106,993); we then analyzed the occurrence of osteoporosis and osteoporotic fracture at baseline from 2004 to 2013 and during follow-up from 2012 to 2016. A logistic regression model was used to analyze the odds ratios (ORs) and the 95% confidence intervals (CIs). Subgroup analysis was performed based on age (younger group aged ≤ 51 years old; older group aged ≥ 52 years old).

Results: The ORs (95% CIs) for osteoporosis and osteoporotic fracture were 1.54 (95% CI = 1.28-1.84, P < 0.001) and 1.01 (95% CI = 0.82-1.23, P = 0.949), respectively, in the breast cancer group. In the subgroup analysis based on age, the ORs (95% CIs) for osteoporosis were 2.41 (95% CI = 1.70-3.43, P < 0.001) in the younger group and 1.33 (95% CI = 1.08-1.64, P = 0.007) in the older group of breast cancer patients. The ORs (95% CIs) for osteoporotic fracture were 1.15 (95% CI = 0.81-1.63, P = 0.441) in the younger group and 0.95 (95% CI = 0.74-1.21, P = 0.661) in the older group of breast cancer patients.

Conclusion: We concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture, regardless of age.

Keywords: Breast cancer; Cohort study; Korea Genome and Epidemiology Study; Nested case–control study; Osteoporosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Jung KW, Won YJ, Kong HJ, Lee ES (2019) Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2016. Cancer Res Treat 51:417–430. https://doi.org/10.4143/crt.2019.138 - DOI - PubMed - PMC
    1. Momenimovahed Z, Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer (Dove Med Press) 11:151–164. https://doi.org/10.2147/BCTT.S176070 - DOI
    1. Tong CWS, Wu M, Cho WCS, To KKW (2018) Recent advances in the treatment of breast cancer. Front Oncol 8:227. https://doi.org/10.3389/fonc.2018.00227 - DOI - PubMed - PMC
    1. Awan A, Esfahani K (2018) Endocrine therapy for breast cancer in the primary care setting. Curr Oncol 25:285–291. https://doi.org/10.3747/co.25.4139 - DOI - PubMed - PMC
    1. Akkawi I, Zmerly H (2018) Osteoporosis: current concepts. Joints 6:122–127. https://doi.org/10.1055/s-0038-1660790 - DOI - PubMed - PMC

Publication types

LinkOut - more resources