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doi: 10.1016/j.tig.2021.06.002.
Epub 2021 Jun 17.
Alternative polyadenylation-associated loci interpret human traits and diseases
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- PMID: 34148698
- DOI: 10.1016/j.tig.2021.06.002
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Alternative polyadenylation-associated loci interpret human traits and diseases
Trends Genet.
2021 Sep.
Abstract
Alternative polyadenylation (APA)-associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.
Keywords: alternative polyadenylation; complex traits; human diseases; quantitative trait loci.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests None declared by authors.
Comment on
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An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.Nat Genet. 2021 Jul;53(7):994-1005. doi: 10.1038/s41588-021-00864-5. Epub 2021 May 13. Nat Genet. 2021. PMID: 33986536
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