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Review
. 2021 Jun 4:12:657033.
doi: 10.3389/fphar.2021.657033. eCollection 2021.

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Qingyun Tan  1 , Yuying Fang  1 , Qiong Gu  1
Affiliations
Review

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Qingyun Tan et al. Front Pharmacol. .

Abstract

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.

Keywords: central nervous system diseases; coenzyme Q10; ferroptosis; glutathione peroxidase 4; iron metabolism; lipid metabolism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The key regulatory mechanisms of ferroptosis. (A) Lipid metabolism. (B) Iron metabolism. (C) Glutathione-dependent pathway. (D) CoQ10-dependent pathway.
FIGURE 2
FIGURE 2
Regulators of ferroptosis. (A–C) Inhibitors of ferroptosis. (D) Inducers of ferroptosis.
FIGURE 3
FIGURE 3
Other factors that regulate ferroptosis.
See this image and copyright information in PMC

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