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. 2021 May 15;13(5):5137-5146.
eCollection 2021.

Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment

Jincai Lin  1 , Ying Shen  1 , Jiyuan Liu  1 , Yinzhu Luo  1 , Xiaoying Ma  1 , Liyan Zhang  1
Affiliations

Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment

Jincai Lin et al. Am J Transl Res. .

Abstract

Objectives: To compare the treatment efficacy of high-frequency oscillatory ventilation (HFOV) with nasal continuous positive airway pressure (NCPAP) in the treatment of neonatal respiratory distress syndrome (NRDS) and its effect on the expression of high-mobility group protein B1 (HMGB1).

Methods: A total of 180 infants with NRDS admitted to our hospital were included and randomly assigned into the HFOV group (receiving conventional therapy and HFOV), the NCPAP group (receiving conventional therapy and NCPAP), and the conventional group (receiving conventional therapy). Qi and blood indicators, heart rate, respiratory frequency, PCO2, and PaO2 were observed and recorded before and after treatment, together with complications after treatment. ELISA was performed for HMGB1 Results: A distinctly lower partial pressure of carbon dioxide (PCO2) but higher arterial partial pressure of oxygen (PaO2) was observed in the HFOV and NCPAP groups than in the conventional group (P < 0.05), whereas infants in the HFOV group exhibited slight differences in these two indicators from their counterparts in the NCPAP group (P > 0.05). The serum HMGB1 levels in both groups were significantly higher than those in the conventional group (P < 0.05).

Discussion: Both HFOV and NCPAP are feasible in the treatment of NRDS and may play a role in the inhibition of HMGB1.

Keywords: HFOV; HMGB1; NCPAP; NRDS; conventional therapy.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of Heart Rate and Respiration Frequency before and after Treatment. Remarkable differences were not found in heart rates among all groups before treatment (P > 0.05), or between the HFOV group and NCPAP group after treatment, although these two groups had much more favorable heart rates than the conventional group (P < 0.05) (A). Significant differences were not found in respiratory frequencies among all groups before treatment (P > 0.05), or between the HFOV group and NCPAP group after treatment, although these two groups had much more favorable respiratory frequencies than the conventional group (P < 0.05) (B). Note: *P < 0.05 after treatment compared with that before treatment, and #P < 0.05 compared with that in conventional group after treatment.
Figure 2
Figure 2
Comparison of PCO2 and PaO2 before and after Treatment. PCO2 and PaO2 varied slightly among the three groups before treatment (P > 0.05). After treatment, PCO2 was much lower in the HFOV and NCPAP groups than that in the conventional group (P < 0.05) (A), while PaO2 was significantly higher than that in the conventional group (P < 0.05) (B). There was no significant difference in PCO2 and PaO2 between the HFOV and NCPAP groups after treatment (P > 0.05). Note: *P < 0.05 after treatment compared with that before treatment, and #P < 0.05 compared with that in conventional group after treatment.
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