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. 2021 May 15;13(5):5484-5490.
eCollection 2021.

The effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding

Yu Duan  1 , Ji Chen  1 , Hong Cui  1 , Cuijuan Zhao  1
Affiliations

The effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding

Yu Duan et al. Am J Transl Res. .

Abstract

Objective: To explore the effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding (UGB) as well as its influence on serum hs-CRP and coagulation function.

Methods: From June 2016 to May 2018, patients with upper gastrointestinal hemorrhage due to non-esophagogastric varices in our hospital were selected as research subjects. After screening, they were randomly divided into the combined group (57 cases) and the control group (57 cases). After the two groups are treated, the therapeutic effect was observed. The two groups of patients were followed up for 6 consecutive months, and the data were statistically analyzed.

Results: It was found that there wass no significant difference between the two groups in gender, age, amount of bleeding, and etiology (P > 0.05). It was found that the immediate hemostasis rate and the hemostasis rate within 24 hours in the combined group were distinctly higher compared to the control group. The difference has statistical significance (P < 0.05). The total effective rate of the combined group was distinctly higher compared to the control group (P < 0.05). By comparing the expression levels of hs-CRP and IL-6 protein in the serum of the two groups before and after treatment, it was found that there was no significant difference in the expression levels of hs-CRP and IL-6 protein before treatment. However, after treatment, it was found that the levels of hs-CRP and IL-6 protein in the combined group were distinctly lower compared to the control group (P < 0.05). By analyzing adverse reactions, it was found that the combined group had distinctly lower adverse reactions compared to the control group (P < 0.05).

Conclusion: This work provides an experimental basis for the diagnosis and treatment of non-esophagogastric varicose UGB in the clinic.

Keywords: Pantoprazole; hs-CRP; somatostatin; thrombin; upper gastrointestinal hemorrhage.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparative analysis of hemostasis between the two groups (A. comparison of hemostasis; B. comparison of hemostasis rate (Compared to the control group, #P < 0.05 was statistically significant, ##P < 0.01 had significant statistical significance)).
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