Evaluation methods for long-term reliability of polymer-based implantable biomedical devices

doi:10.1007/s13534-021-00188-7

Review

. 2021 Apr 15;11(2):97-105.

doi: 10.1007/s13534-021-00188-7. eCollection 2021 May.

Evaluation methods for long-term reliability of polymer-based implantable biomedical devices

Dong Hyeon Lee¹, Chae Hyun Kim², Jiman Youn³, Joonsoo Jeong^{3

4}

Affiliations

¹ School of Mechanical Engineering, Pusan National University, Pusan, 46241 South Korea.
² Department of Biomedical Engineering, Pusan National University, Yangsan, 50612 South Korea.
³ Department of Information Convergence Engineering, Pusan National University, Yangsan, 50612 South Korea.
⁴ School of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612 South Korea.

PMID: 34150346
PMCID: PMC8155150
DOI: 10.1007/s13534-021-00188-7

Review

Evaluation methods for long-term reliability of polymer-based implantable biomedical devices

Dong Hyeon Lee et al. Biomed Eng Lett. 2021.

. 2021 Apr 15;11(2):97-105.

doi: 10.1007/s13534-021-00188-7. eCollection 2021 May.

Authors

Dong Hyeon Lee¹, Chae Hyun Kim², Jiman Youn³, Joonsoo Jeong^{3

4}

Affiliations

¹ School of Mechanical Engineering, Pusan National University, Pusan, 46241 South Korea.
² Department of Biomedical Engineering, Pusan National University, Yangsan, 50612 South Korea.
³ Department of Information Convergence Engineering, Pusan National University, Yangsan, 50612 South Korea.
⁴ School of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612 South Korea.

PMID: 34150346
PMCID: PMC8155150
DOI: 10.1007/s13534-021-00188-7

Abstract

Long-term reliability of implantable biomedical devices is a critical issue for their practical usefulness and successful translation into clinical application. Reliability is particularly of great concern for recently demonstrated devices based on new materials typically relying on polymeric thin films and microfabrication process. While reliability testing protocol has been well-established for traditional metallic packages, common evaluation methods for polymer-based microdevices has yet to be agreed upon, even though various testing methods have been proposed. This article is aiming to summarize the evaluation methods on long-term reliability of emerging biomedical implants based on polymeric thin-films in terms of their theories and implementation with specific focus on difference from the traditional metallic packages.

Keywords: Accelerated aging; Aging test; Hermeticity; Long-term reliability; Polymer packaging.

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Conflict of interest statement

Conflict of interestAll the authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Illustration of leaking mechanisms in conventional metallic packages (a) and polymer-based devices (b)

See this image and copyright information in PMC

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References

1. Scholten K, Meng E. Materials for microfabricated implantable devices: a review. Lab Chip. 2015;15(22):4256–4272. - PubMed
1. Fattahi P, Yang G, Kim G, Abidian MR. A review of organic and inorganic biomaterials for neural interfaces. Adv Mater. 2014;26(12):1846–1885. - PMC - PubMed
1. Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess DJ. A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J Diabetes Sci Technol. 2008;2(6):1003–1015. - PMC - PubMed
1. Kim C, Jeong J, Kim SJ. Recent progress on non-conventional microfabricated probes for the chronic recording of cortical neural activity. Sensors. 2019;19(5):1–23. - PMC - PubMed
1. Ordonez J, Schuettler M, Boehler C, Boretius T, Stieglitz T. Thin films and microelectrode arrays for neuroprosthetics. MRS Bull. 2012;37(6):590–598.

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[1] Scholten K, Meng E. Materials for microfabricated implantable devices: a review. Lab Chip. 2015;15(22):4256–4272. - PubMed

[2] Scholten K, Meng E. Materials for microfabricated implantable devices: a review. Lab Chip. 2015;15(22):4256–4272. - PubMed

[3] Fattahi P, Yang G, Kim G, Abidian MR. A review of organic and inorganic biomaterials for neural interfaces. Adv Mater. 2014;26(12):1846–1885. - PMC - PubMed

[4] Fattahi P, Yang G, Kim G, Abidian MR. A review of organic and inorganic biomaterials for neural interfaces. Adv Mater. 2014;26(12):1846–1885. - PMC - PubMed

[5] Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess DJ. A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J Diabetes Sci Technol. 2008;2(6):1003–1015. - PMC - PubMed

[6] Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess DJ. A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J Diabetes Sci Technol. 2008;2(6):1003–1015. - PMC - PubMed

[7] Kim C, Jeong J, Kim SJ. Recent progress on non-conventional microfabricated probes for the chronic recording of cortical neural activity. Sensors. 2019;19(5):1–23. - PMC - PubMed

[8] Kim C, Jeong J, Kim SJ. Recent progress on non-conventional microfabricated probes for the chronic recording of cortical neural activity. Sensors. 2019;19(5):1–23. - PMC - PubMed

[9] Ordonez J, Schuettler M, Boehler C, Boretius T, Stieglitz T. Thin films and microelectrode arrays for neuroprosthetics. MRS Bull. 2012;37(6):590–598.

[10] Ordonez J, Schuettler M, Boehler C, Boretius T, Stieglitz T. Thin films and microelectrode arrays for neuroprosthetics. MRS Bull. 2012;37(6):590–598.

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Evaluation methods for long-term reliability of polymer-based implantable biomedical devices

Affiliations

Evaluation methods for long-term reliability of polymer-based implantable biomedical devices

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Affiliations

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Conflict of interest statement

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