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Editorial
. 2021 Jun 22;143(25):2471-2474.
doi: 10.1161/CIRCULATIONAHA.121.054900. Epub 2021 Jun 21.

Integrative Multiomics Approaches for Discovery of New Drug Targets for Cardiovascular Disease

Muredach P Reilly  1 , Karin E Bornfeldt  2   3
Affiliations
Editorial

Integrative Multiomics Approaches for Discovery of New Drug Targets for Cardiovascular Disease

Muredach P Reilly et al. Circulation. .
No abstract available

Keywords: Editorials; macrophages; peroxisome proliferator-activated receptors; proteomics; transplants; veins.

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Figures

Figure 1.
Figure 1.. Model for discovery and validation of novel drug targets for complex diseases using integrative single-cell non-biased -omics.
A discovery phase using both human disease and animal model single cell -omics profiling is recommended. Integrative computational methods are applied to cross-species and cross-platform data to identify and prioritize master regulatory and druggable targets of greatest importance in human disease. Experimental functional studies in animal models of disease and in disease-relevant human cells, including gene-manipulation in human induced pluripotent stems cells, can define precise molecular and cellular targets for translation via clinical trials and precision therapeutic strategies. Figure created with BioRender.com.
See this image and copyright information in PMC

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References

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